Recombinant human IL-1R beta/IL1R2 protein | NKMAX ATGP3733 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human IL-1R beta/IL1R2 protein

catalog :

ATGP3733

quantity :

10 ug

price :

150 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human IL-1R beta/IL1R2 protein

Domain :

14-343aa

Catalog number (SKU) :

ATGP3733

NCBI :

NP_004624.1

Description :

IL1R2, also known as interleukin-1 receptor type 2 isoform 1, is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is expressed predominantly by, T cells, fibroblasts and endothelial cells. It binds interleukin-1 alpha (IL1A), interleukin-1beta (IL1B), and interleukin 1 receptor antagonist (IL1RN), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling. Also, Interleukin-4 (IL4) is reported to antagonize the activity of interleukin-1 by inducing the expression and release of this cytokine. Recombinant human IL1R2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Interleukin-1 receptor type 2, CD121 antigen-like family member B, CDw121b, IL-1 type II receptor, Interleukin-1 receptor beta, IL-1R-beta, Interleukin-1 receptor type II, CD121b, IL1RB

Concentration :

0.5mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Greenfeder SA., et al, (1995) J Biol Chem 270:13757-13765.;; Granowitz EV., et al, (1991) J. Biol. Chem. 266:14147-14150.

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

Measured by its ability to inhibit proliferation using D10.G4.1 mouse helper T cells. The ED50 range ≤400ng/ml with Human IL-1 beta/IL-1F2.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Hormones & Cytokines

Molecular Weight :

38.8 kDa (338aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Measured by its ability to inhibit proliferation using D10.G4.1 mouse helper T cells. The ED50 range ≤400 ng/ml with Human IL-1 beta/IL-1F2.

Amino Acid Sequence :

FTLQPAAHTG AARSCRFRGR HYKREFRLEG EPVALRCPQV PYWLWASVSP RINLTWHKND SARTVPGEEE TRMWAQDGAL WLLPALQEDS GTYVCTTRNA SYCDKMSIEL RVFENTDAFL PFISYPQILT LSTSGVLVCP DLSEFTRDKT DVKIQWYKDS LLLDKDNEKF LSVRGTTHLL VHDVALEDAG YYRCVLTFAH EGQQYNITRS IELRIKKKKE ETIPVIISPL KTISASLGSR LTIPCKVFLG TGTPLTTMLW WTANDTHIES AYPGGRVTEG PRQEYSENNE NYIEVPLIFD PVTREDLHMD FKCVVHNTLS FQTLRTTVKE

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Phe14

Product Type Name :

Recombinant Protein

UniProt No. :

P27930

Internal Search Terms :

IL1 RII,ATGP3733-10ug,ATGP3733-20ug,ATGP3733-50ug,ATGP3733-100ug,ATGP3733-250ug,ATGP3733-500ug,ATGP3733-1mg,ATGP3733-10,ATGP3733-20,ATGP3733-50,ATGP3733-100,ATGP3733-250,ATGP3733-500,ATGP3733-1

more info or order :

NKMAX product webpage