Recombinant human TRAILR2/TNFRSF10B protein | NKMAX ATGP3732 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human TRAILR2/TNFRSF10B protein

catalog :

ATGP3732

quantity :

10 ug

price :

81 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human TRAILR2/TNFRSF10B protein

Domain :

56-210aa

Catalog number (SKU) :

ATGP3732

NCBI :

NP_003833

Description :

TNFRSF10B, also known as tumor necrosis factor receptor superfamily member 10B isoform 1, is a member of receptors for the cytotoxic ligand TNFSF10/TRAIL. It can be activated by tumor necrosis factor-related apoptosis inducing ligand, and transduces an apoptosis signal. This protein promotes the activation of NF-kappa-B. Defects in this protein causes of head and neck squamous cell carcinomas. Recombinant human TNFRSF10B protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Tumor necrosis factor receptor superfamily member 10B isoform 1, TNFRSF10B, CD262, Death receptor 5, DR5, KILLER, KILLER/DR5, TRAIL receptor 2, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9

Concentration :

1mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Finnberg NK., et al, (2016) Cancer Res. 76:700-712.;; Shin GC., et al, (2016) Autophagy. 12:2451-2466.

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

Measured by its ability to inhibit cytotoxicity using Jurkat human acute T cell leukemia cells. The ED50 range ≤5ng/ml with Human TRAIL.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Apoptosis

Molecular Weight :

43.9 kDa (394aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Measured by its ability to inhibit cytotoxicity using Jurkat human acute T cell leukemia cells. The ED50 range ≤5 ng/ml with Human TRAIL.

Amino Acid Sequence :

ITQQDLAPQQ RAAPQQKRSS PSEGLCPPGH HISEDGRDCI SCKYGQDYST HWNDLLFCLR CTRCDSGEVE LSPCTTTRNT VCQCEEGTFR EEDSPEMCRK CRTGCPRGMV KVGDCTPWSD IECVHKESGT KHSGEVPAVE ETVTSSPGTP ASPCS

Tag :

hIgG-His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ile56

Product Type Name :

Recombinant Protein

UniProt No. :

O14763

Internal Search Terms :

TRAIL R2, TNFRSF10B,ATGP3732-10ug,ATGP3732-20ug,ATGP3732-50ug,ATGP3732-100ug,ATGP3732-250ug,ATGP3732-500ug,ATGP3732-1mg,ATGP3732-10,ATGP3732-20,ATGP3732-50,ATGP3732-100,ATGP3732-250,ATGP3732-500,ATGP3732-1

more info or order :

NKMAX product webpage