product summary
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company name :
NKMAX
product type :
protein
product name :
Recombinant human IL-15R alpha/IL15RA protein
catalog :
ATGP3672
quantity :
10 ug
price :
94 USD
more info or order :
product information
Product Type :
Proteins
Item Name :
Recombinant human IL-15R alpha/IL15RA protein
Domain :
31-205aa
Catalog number (SKU) :
ATGP3672
NCBI :
NP_002180
Description :
IL15RA, also known as interleukin-15 receptor subunit alpha isoform 1, is a high-affinity receptor for interleukin-15. It associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. This protein can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. IL15/IL15R alpha complexes can transmit reverse signaling that promotes cellular adhesion, tyrosine phosphorylation of intracellular proteins, and cytokine secretion by the IL 15/IL15R alpha expressing cells. Recombinant human IL15RA protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Alternative Names :
Interleukin-15 receptor subunit alpha isoform 1, IL15RA, CD215, IL-15 receptor subunit alpha
Concentration :
0.5mg/ml (determined by absorbance at 280nm)
Formulation :
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Storage :
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
General References :
Epardaud M., et al, (2008) Cancer Res. 68:2972-2983.;; Stoklasek TA., et al, (2006) J Immunol. 177:6072-6080.
Purity :
> 90% by SDS-PAGE
Bioactivity Comment Only :
Measured by its ability to inhibit proliferation using CTLL2 mouse cytotoxic T cells. The ED50 for this effect is ≤2ng/ml with Human IL-15.
Applications :
SDS-PAGE, Bioactivity
Antigen Species :
Human
Gene Category :
Apoptosis
Molecular Weight :
45.6 kDa (417aa)
Endotoxin :
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment and Pics :
Human IL-15 R alpha inhibits Human IL-15 induced cell proliferation in the CTLL2 mouse cytotoxic T cells. The ED50 range ≤2 ng/ml
Amino Acid Sequence :
ITCPPPM SVEHADIWVK SYSLYSRERY ICNSGFKRKA GTSSLTECVL NKATNVAHWT TPSLKCIRDP ALVHQRPAPP STVTTAGVTP QPESLSPSGK EPAASSPSSN NTAATTAAIV PGSQLMPSKS PSTGTTEISS HESSHGTPSQ TTAKNWELTA SASHQPPGVY PQGHSDTT
Tag :
hIgG-His-Tag
Expression System :
Baculovirus
Predicted nterm :
Ala
Product Type Name :
Recombinant Protein
UniProt No. :
Q13261
Internal Search Terms :
IL15 R a,ATGP3672-10ug,ATGP3672-20ug,ATGP3672-50ug,ATGP3672-100ug,ATGP3672-250ug,ATGP3672-500ug,ATGP3672-1mg,ATGP3672-10,ATGP3672-20,ATGP3672-50,ATGP3672-100,ATGP3672-250,ATGP3672-500,ATGP3672-1
more info or order :
company information
NKMAX
SNUH Health Care Innovation Park 6F
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
https://www.nkmaxbio.com172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
82-31-8017-8114
headquarters: South Korea
NKMAX Co. Ltd. is a biotech company that manufactures and supplies a unique line of quality proteins and antibodies worldwide to both researchers and retailers.