Recombinant human NKG2D/KLRK1 protein | NKMAX ATGP3662 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human NKG2D/KLRK1 protein

catalog :

ATGP3662

quantity :

10 ug

price :

121 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human NKG2D/KLRK1 protein

Domain :

73-216aa

Catalog number (SKU) :

ATGP3662

NCBI :

NP_031386.2

Description :

KLRK1, also known as NKG2D ligand 4 isoform 1, is a type ll transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands. It can send co-stimulatory signals to activate CD8 T cells. Also, it plays an important role in viral control. Cellular stress can induce ligands for KLRK1 which results in the cell susceptible to NK cell-mediated lysis. Recombinant human KLRK1, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Killer cell lectin like receptor K1, Killer cell lectin-like receptor subfamily K member 1, NKG2-D type II integral membrane protein, NK cell receptor D, NKG2-D-activating NK receptor, CD314, NKG2D, KLR, NKG2-D

Concentration :

0.5mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Bauer S., et al, (1999) Science 285:727-729. ;; Raulet DH., (2003) Nat. Rev. Immunol. 3:781-790.

Purity :

> 95% by SDS-PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with Human ULBP-6/RAET1L (CAT# ATGP4023). The ED50 range ≤ 1.5 ug/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

43.9 kDa (386aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human ULBP-6/RAET1L (CAT# ATGP4023) is coated at 10 ug/ml (100 ul/well) can bind Human NKG2D. The ED50 range ≤ 1.5 ug/ml.

Amino Acid Sequence :

IWSAVFL NSLFNQEVQI PLTESYCGPC PKNWICYKNN CYQFFDESKN WYESQASCMS QNASLLKVYS KEDQDLLKLV KSYHWMGLVH IPTNGSWQWE DGSILSPNLL TIIEMQKGDC ALYASSFKGY IENCSTPNTY ICMQRTV

Tag :

hIgG-His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

P26718

Internal Search Terms :

NKG2D, NKG2-D type II integral membrane protein, KLRK1, CD314, D12S2489E, KLR, NKG2-D, NKG2D,ATGP3662-10ug,ATGP3662-20ug,ATGP3662-50ug,ATGP3662-100ug,ATGP3662-250ug,ATGP3662-500ug,ATGP3662-1mg,ATGP3662-10,ATGP3662-20,ATGP3662-50,ATGP3662-100,ATGP3662-250,ATGP3662-500,ATGP3662-1

more info or order :

NKMAX product webpage