Recombinant human UMPS protein | NKMAX ATGP3659 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human UMPS protein

catalog :

ATGP3659

quantity :

10 ug

price :

150 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human UMPS protein

Domain :

1-480aa

Catalog number (SKU) :

ATGP3659

NCBI :

NP_000364.1

Description :

UMPS, also known as uridine 5'-monophosphate synthase, is a bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis. It is an indispensable component in this metabolic pathway and is a target for antimalarial and antitumor drugs. Its expression in colorectal carcinoma tissues is not correlated with the toxicities of 5-FU-based regimen, but It in the normal tissues can help predict the toxicities associated with 5-FU. Recombinant human UMPS, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Uridine 5'-monophosphate synthase, UMPS, OPRT

Concentration :

0.25mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 30% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Zhang Y., et al. (2013) J Biol Chem. 288:34746-34754.;; Dong Q., et al. (2012) Nan Fang Yi Ke Da Xue Xue Bao. 32:1179-1181.

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Epigenomics (Transcription & Translation)

Molecular Weight :

53 kDa (486aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

MAVARAALGP LVTGLYDVQA FKFGDFVLKS GLSSPIYIDL RGIVSRPRLL SQVADILFQT AQNAGISFDT VCGVPYTALP LATVICSTNQ IPMLIRRKET KDYGTKRLVE GTINPGETCL IIEDVVTSGS SVLETVEVLQ KEGLKVTDAI VLLDREQGGK DKLQAHGIRL HSVCTLSKML EILEQQKKVD AETVGRVKRF IQENVFVAAN HNGSPLSIKE APKELSFGAR AELPRIHPVA SKLLRLMQKK ETNLCLSADV SLARELLQLA DALGPSICML KTHVDILNDF TLDVMKELIT LAKCHEFLIF EDRKFADIGN TVKKQYEGGI FKIASWADLV NAHVVPGSGV VKGLQEVGLP LHRGCLLIAE MSSTGSLATG DYTRAAVRMA EEHSEFVVGF ISGSRVSMKP EFLHLTPGVQ LEAGGDNLGQ QYNSPQEVIG KRGSDIIIVG RGIISAADRL EAAEMYRKAA WEAYLSRLGV

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Met1

Product Type Name :

Recombinant Protein

UniProt No. :

P11172

Internal Search Terms :

UMPS, Uridine 5'-monophosphate synthase, UMPS, OPRT,ATGP3659-10ug,ATGP3659-20ug,ATGP3659-50ug,ATGP3659-100ug,ATGP3659-250ug,ATGP3659-500ug,ATGP3659-1mg,ATGP3659-10,ATGP3659-20,ATGP3659-50,ATGP3659-100,ATGP3659-250,ATGP3659-500,ATGP3659-1

more info or order :

NKMAX product webpage