Recombinant human TWEAKR/TNFRSF12A protein | NKMAX ATGP3624 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human TWEAKR/TNFRSF12A protein

catalog :

ATGP3624

quantity :

10 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human TWEAKR/TNFRSF12A protein

Domain :

28-80aa

Catalog number (SKU) :

ATGP3624

NCBI :

NP_057723

Description :

TNFRSF12A, also known as tumor necrosis factor receptor superfamily member 12A, is the sole signaling receptor for the proinflammatory cytokine TWEAK (TNFSF12). It is a Downstream Target of the TGF-b Signaling Pathway and regulates Fibroblast Activation. It promotes oxidative stress through NADPH oxidase activation in macrophages. It is responsible for TWEAK-induced proliferation of endothelial cells and angiogenesis. Recombinant human TNFRSF12A, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Tumor necrosis factor receptor superfamily member 12A, Fibroblast growth factor-inducible immediate-early response protein 14, FGF-inducible 14, Tweak-receptor, TweakR, CD266, FN14

Concentration :

1mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 1mM DTT, 20% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Nakayama M., et al. (2003) J Immunol. 170:341-348.;; Madrigal-Matute J., et al. (2015) Cardiovasc Res. 108:139-147.

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Cardiovascular

Molecular Weight :

32.6 kDa (292aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP

Tag :

hIgG-His-Tag

Expression System :

Baculovirus

Predicted nterm :

Glu28

Product Type Name :

Recombinant Protein

UniProt No. :

Q9NP84

Internal Search Terms :

CD 266, CD266, FGF inducible 14, FGF-inducible 14, Fibroblast growth factor-inducible immediate-early response protein 14, FN14, TNFRSF12A, Tumor necrosis factor receptor superfamily member 12A, TWEAK R, Tweak receptor, TWEAK TNFRSF12, TWEAKR, Tweak-receptor, ATGP3624-10ug, ATGP3624-20ug, ATGP3624-50ug, ATGP3624-100ug, ATGP3624-250ug, ATGP3624-500ug, ATGP3624-1mg, ATGP3624-010, ATGP3624-020, ATGP3624-050, ATGP3624-100, ATGP3624-250, ATGP3624-500, ATGP3624-01M

more info or order :

NKMAX product webpage