protein

Recombinant human B7-H4 protein

ATGP3607

10 ug

240 USD

Recombinant human B7-H4 protein

25-259aa

ATGP3607

NP_078902.2

VTCN1, also known as v-set domain-containing T-cell activation inhibitor 1 isoform 1, is a member of the costimulatory B7 family. It has been found to be widely expressed in many kinds of tumor tissues and to play an important part in tumor progression and poor prognosis. It serves a critical role in the negative regulation of T cell-mediated antitumor immune responses. It facilitates proliferation of esophageal squamous cell carcinoma cells through promoting interleukin-6/signal transducer and activator of transcription 3 pathway activation. Recombinant human VTCN1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

V-set domain-containing T-cell activation inhibitor 1 isoform 1, VTCN1, B7-H4, B7h.5, B7H4, B7S1, B7X, PRO1291

0.25mg/ml (determined by absorbance at 280nm)

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Zeng S., et al. (2016) Mol Biol. 50:1007-1013.;; Chen X., et al. (2016) Cancer Sci. 107:944-954.

> 90% by SDS-PAGE

SDS-PAGE

Human

Cell Cycle

26.9 kDa (244aa)

< 1 EU per 1ug of protein (determined by LAL method)

LIIGFGI SGRHSITVTT VASAGNIGED GILSCTFEPD IKLSDIVIQW LKEGVLGLVH EFKEGKDELS EQDEMFRGRT AVFADQVIVG NASLRLKNVQ LTDAGTYKCY IITSKGKGNA NLEYKTGAFS MPEVNVDYNA SSETLRCEAP RWFPQPTVVW ASQVDQGANF SEVSNTSFEL NSENVTMKVV SVLYNVTINN TYSCMIENDI AKATGDIKVT ESEIKRRSHL QLLNSKAS

His-Tag

Baculovirus

Ala

Recombinant Protein

Q7Z7D3

B7-H4, V-set domain-containing T-cell activation inhibitor 1 isoform 1, VTCN1, B7-H4, B7h.5, B7H4, B7S1, B7X, PRO1291,ATGP3607-10ug,ATGP3607-20ug,ATGP3607-50ug,ATGP3607-100ug,ATGP3607-250ug,ATGP3607-500ug,ATGP3607-1mg,ATGP3607-10,ATGP3607-20,ATGP3607-50,ATGP3607-100,ATGP3607-250,ATGP3607-500,ATGP3607-1