Recombinant human Adenosylhomocysteinease/AHCY protein | NKMAX ATGP3578 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Adenosylhomocysteinease/AHCY protein

catalog :

ATGP3578

quantity :

4 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Adenosylhomocysteinease/AHCY protein

Domain :

1-432aa

Catalog number (SKU) :

ATGP3578

NCBI :

NP_000678

Description :

AHCY, also known as adenosylhomocysteinase isoform 1, is an enzyme that catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). AdoHcy hydrolysis is a reversible reaction with an equilibrium favoring AdoHcy formation, but hydrolysis prevails under physiological conditions due to the rapid removal of adenosine and homocysteine. Thus, AHCYs activity in mammals is directly related to homocysteine level, an independent risk factor for vascular disease. It also functions as a regulator of biological transmethylation by controlling the concentration of AdoHcy, a potent competitive inhibitor of all S-adenosyl-L-methionine methyltransferases. Recombinant human AHCY protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Adenosylhomocysteinase isoform 1, AHCY, AdoHcyase, SAHH, S-adenosylhomocysteine hydrolase

Concentration :

0.25mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Vugrek O. et al., (2009) Hum Mutat. 30: E555-65.;; Park SJ. et al., (2015) Am J Cancer Res. 5: 2127-2138.

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Signal Transduction

Molecular Weight :

48.8 kDa (441aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

MSDKLPY KVADIGLAAW GRKALDIAEN EMPGLMRMRE RYSASKPLKG ARIAGCLHMT VETAVLIETL VTLGAEVQWS SCNIFSTQDH AAAAIAKAGI PVYAWKGETD EEYLWCIEQT LYFKDGPLNM ILDDGGDLTN LIHTKYPQLL PGIRGISEET TTGVHNLYKM MANGILKVPA INVNDSVTKS KFDNLYGCRE SLIDGIKRAT DVMIAGKVAV VAGYGDVGKG CAQALRGFGA RVIITEIDPI NALQAAMEGY EVTTMDEACQ EGNIFVTTTG CIDIILGRHF EQMKDDAIVC NIGHFDVEID VKWLNENAVE KVNIKPQVDR YRLKNGRRII LLAEGRLVNL GCAMGHPSFV MSNSFTNQVM AQIELWTHPD KYPVGVHFLP KKLDEAVAEA HLGKLNVKLT KLTEKQAQYL GMSCDGPFKP DHYRY

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

P23526

Internal Search Terms :

Adenosylhomocysteinease, AHCY, Adenosylhomocysteinase isoform 1, AHCY, adoHcyase, SAHH,ATGP3578-10ug,ATGP3578-20ug,ATGP3578-50ug,ATGP3578-100ug,ATGP3578-250ug,ATGP3578-500ug,ATGP3578-1mg,ATGP3578-10,ATGP3578-20,ATGP3578-50,ATGP3578-100,ATGP3578-250,ATGP3578-500,ATGP3578-1

more info or order :

NKMAX product webpage