Recombinant human Osteoactivin/GPNMB protein | NKMAX ATGP3523 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Osteoactivin/GPNMB protein

catalog :

ATGP3523

quantity :

10 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Osteoactivin/GPNMB protein

Domain :

22-474aa

Catalog number (SKU) :

ATGP3523

NCBI :

NP_002501.1

Description :

GPNMB, also known as glycoprotein nmb, is a transmembrane glycoprotein that is expressed in numerous cells, including osteoclasts, macrophages, dendritic cells, and tumor cells. It shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. This protein participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages. It may be involved in growth delay and reduction of metastatic potential. Recombinant human GPNMB protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Transmembrane glycoprotein NMB, Glycoprotein NMB, Glycoprotein nonmetastatic melanoma protein B, Hematopoietic growth factor inducible neurokinin-1, HGFIN

Concentration :

0.5mg/ml (determined by BCA assay)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Huang JJ., et al. (2012) Brain Behav. 2: 85-96.;; Kumagai K., et al. (2015) PLoS One. 10: e0143413.

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

51.8 kDa (462aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

AKRFHDV LGNERPSAYM REHNQLNGWS SDENDWNEKL YPVWKRGDMR WKNSWKGGRV QAVLTSDSPA LVGSNITFAV NLIFPRCQKE DANGNIVYEK NCRNEAGLSA DPYVYNWTAW SEDSDGENGT GQSHHNVFPD GKPFPHHPGW RRWNFIYVFH TLGQYFQKLG RCSVRVSVNT ANVTLGPQLM EVTVYRRHGR AYVPIAQVKD VYVVTDQIPV FVTMFQKNDR NSSDETFLKD LPIMFDVLIH DPSHFLNYST INYKWSFGDN TGLFVSTNHT VNHTYVLNGT FSLNLTVKAA APGPCPPPPP PPRPSKPTPS LGPAGDNPLE LSRIPDENCQ INRYGHFQAT ITIVEGILEV NIIQMTDVLM PVPWPESSLI DFVVTCQGSI PTEVCTIISD PTCEITQNTV CSPVDVDEMC LLTVRRTFNG SGTYCVNLTL GDDTSLALTS TLISVP

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

Q14956

Internal Search Terms :

GPNMB, Glycoprotein nmb, GPNMB, NMB, HGFIN,ATGP3523-10ug,ATGP3523-20ug,ATGP3523-50ug,ATGP3523-100ug,ATGP3523-250ug,ATGP3523-500ug,ATGP3523-1mg,ATGP3523-10,ATGP3523-20,ATGP3523-50,ATGP3523-100,ATGP3523-250,ATGP3523-500,ATGP3523-1

more info or order :

NKMAX product webpage