protein

Recombinant human TDP-43/TARDBP protein

ATGP3502

10 ug

240 USD

Recombinant human TDP-43/TARDBP protein

1-414aa

ATGP3502

NP_031401.1

TARDBP, as known as TAR DNA binding protein 43, was originally identified as a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. It has also been identified in individuals diagnosed with chronic traumatic encephalopathy, a condition that often mimics ALS and that has been associated with athletes who have experienced multiple concussions and other types of head injury. It has been shown to bind both DNA and RNA and have multiple functions in transcriptional repression, pre-mRNA splicing and translational regulation. Recombinant human TARDBP protein was expressed in E. coli and purified by using conventional chromatography.

TAR DNA binding protein 43, ALS10, TDP-43

0.25mg/ml (determined by Bradford assay)

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 1mM DTT, 1mM EDTA, 10% glycerol

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Ou SH., et al. (1995) J Virol. 69(6):3584-96.

> 85% by SDS-PAGE

SDS-PAGE

Human

Epigenomics (Transcription & Translation)

44.7 kDa (414aa)

MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV QKTSDLIVLG LPWKTTEQDL KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS KQSQDEPLRS RKVFVGRCTE DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADDQIA QSLCGEDLII KGISVHISNA EPKHNSNRQL ERSGRFGGNP GGFGNQGGFG NSRGGGAGLG NNQGSNMGGG MNFGAFSINP AMMAAAQAAL QSSWGMMGML ASQQNQSGPS GNNQNQGNMQ REPNQAFGSG NNSYSGSNSG AAIGWGSASN AGSGSGFNGG FGSSMDSKSS GWGM

Non-Tagged

E.coli

Recombinant Protein

Q13148

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Ko VI, et al, CK1δ/ε kinases regulate TDP-43 phosphorylation and are therapeutic targets for ALS-related TDP-43 hyperphosphorylation. (Neurobiol Dis. 2024){https://pubmed.ncbi.nlm.nih.gov/38677657/}