Recombinant human CD46 protein | NKMAX ATGP3451 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human CD46 protein

catalog :

ATGP3451

quantity :

10 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human CD46 protein

Domain :

35-313aa

Catalog number (SKU) :

ATGP3451

NCBI :

NP_758860

Description :

CD46, also known as membrane cofactor protein isoform 14, is a type 1 membrane protein that plays an important inhibitory role in the complement system. It is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic-uremic syndrome, a disease characterized by uncontrolled complement activation. Recombinant human CD46, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Membrane cofactor protein isoform 14, CD46, AHUS2, MCP, MIC10, TLX, TRA2.10

Concentration :

0.5mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Lublin DM., et al. (1988) J Exp Med. 168:181-194.;; Maga TK., et al. (2010) Hum. Mutat. 31:E1445-14460.

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

32.5 kDa (288aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

ADLCEEPPTF EAMELIGKPK PYYEIGERVD YKCKKGYFYI PPLATHTICD RNHTWLPVSD DACYRETCPY IRDPLNGQAV PANGTYEFGY QMHFICNEGY YLIGEEILYC ELKGSVAIWS GKPPICEKVL CTPPPKIKNG KHTFSEVEVF EYLDAVTYSC DPAPGPDPFS LIGESTIYCG DNSVWSRAAP ECKVVKCRFP VVENGKQISG FGKKFYYKAT VMFECDKGFY LDGSDTIVCD SNSTWDPPVP KCLKGPRPTY KPPVSNYPGY PKPEEGILDS LDHHHHHH

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

P15529

Internal Search Terms :

CD46, Membrane cofactor protein isoform 14, CD46, AHUS2, MCP, MIC10, TLX, TRA2.10,ATGP3451-10ug,ATGP3451-20ug,ATGP3451-50ug,ATGP3451-100ug,ATGP3451-250ug,ATGP3451-500ug,ATGP3451-1mg,ATGP3451-10,ATGP3451-20,ATGP3451-50,ATGP3451-100,ATGP3451-250,ATGP3451-500,ATGP3451-1

more info or order :

NKMAX product webpage