protein

Recombinant human Chitinase 3-like 1/CHI3L1 protein

ATGP3405

10 ug

240 USD

Recombinant human Chitinase 3-like 1/CHI3L1 protein

22-383aa

ATGP3405

NP_001267

CHI3L1, also known as chitinase-3-like protein 1, is a member of the glycosyl hydrolase 18 family. This protein can bind heparins, probably as heparin sulfate. It has been found to enhance cell adhesion and promote cell signaling, proliferation and tumor angiogenesis. Elevated serum CHI3L1 levels occur in some conditions characterized by inflammation and connective tissue remodeling such as arthritis, chronic obstructive pulmonary disease, diabetes, cardiovascular disease, inflammatory bowel disease, and liver cirrhosis. Recombinant human CHI3L1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques

chitinase 3-like 1, cartilage glycoprotein-39, CGP-39; GP-39; hCGP-39, YKL40, YKL-40, YK-40, 39 kDa synovial protein, ASRT7

0.25mg/ml (determined by absorbance at 280nm)

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol, 1mM DTT

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Hakala BE., et al. (1993) J Biol Chem 268:25803-25810.;; Eurich K., et al. (2009) World J Gastroenterol. 15:5249-5259.;;

> 90% by SDS-PAGE

SDS-PAGE

Human

Signal Transduction

41.4 kDa (370aa)

< 1 EU per 1ug of protein (determined by LAL method)

YKLVCYYTSW SQYREGDGSC FPDALDRFLC THIIYSFANI SNDHIDTWEW NDVTLYGMLN TLKNRNPNLK TLLSVGGWNF GSQRFSKIAS NTQSRRTFIK SVPPFLRTHG FDGLDLAWLY PGRGDKQHFT TLIKEMKAEF IKEAQPGKKQ LLLSAALSAG KVTIDSSYDI AKISQHLDFI SIMTYDFHGA WRGTTGHHSP LFRGQEDASP DRFSNTDYAV GYMLRLGAPA SKLVMGIPTF GRSFTLASSE TGVGAPISGP GIPGRFTKEA GTLAYYEICD FLRGATVHRI LGQQVPYATK GNQWVGYDDQ ESVKSKVQYL KDRQLAGAMV WALDLDDFQG SFCGQDLRFP LTNAIKDALA AT

His-Tag

Baculovirus

Tyr22

Recombinant Protein

P36222

Chitinase3-like1, Chitinase-3-like protein 1 , CHI3L1, ASRT7, CGP-39, GP-39, GP39, HC-gp39, hCGP-39, HCGP-3P, YKL-40, YYL-40, 39 kDa synovial protein, ASRT7, Cartilage glycoprotein 39CGP-39, CGP39, CH3L1_HUMAN, CHI3L1, chitinasechitinase 3 like 1, chitinase 3 like 1 (cartilage glycoprotein 39), Chitinase 3 like protein 1 precursorChitinase-3-like protein 1, Chondrocyte protein YKL40GP 39, GP-39, GP39, HC gp39, HCGP 3P, hCGP-39HCgp39, YKL 40, YKL-40, YKL40, YYL 40,ATGP3405-10ug,ATGP3405-20ug,ATGP3405-50ug,ATGP3405-100ug,ATGP3405-250ug,ATGP3405-500ug,ATGP3405-1mg,ATGP3405-10,ATGP3405-20,ATGP3405-50,ATGP3405-100,ATGP3405-250,ATGP3405-500,ATGP3405-1

Suzuki H, et al. YKL-40 Promotes Proliferation of Cutaneous T-Cell Lymphoma Tumor Cells through Extracellular Signal-Regulated Kinase Pathways. (J Invest Dermatol. 2020){https://pubmed.ncbi.nlm.nih.gov/31622598/}