protein

Recombinant human u-Plasminogen Activator/Urokinase protein

ATGP3383

10 ug

120 USD

Recombinant human u-Plasminogen Activator/Urokinase protein

21-431aa

ATGP3383

NP_002649.1

PLAU, also known as urokinase-type plasminogen activator, is a serine protease which converts plasminogen to plasmin. It is a broad-spectrum protease active on extracellular matrix (ECM) components. It is involved in complement activation, cell migration, wound healing, and generation of localized extracellular proteolysis during tissue remodeling, pro-hormone conversion, carcinogenesis and neoplasia. Recombinant human PLAU, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Urokinase-type plasminogen activator, PLAU, ATF, BDPLT5, QPD, u-PA, UPA, URK, Endothelial plasminogen activator inhibitor, PAI, PAI 1, PLANH1, Plasminogen activator inhibitor 1, Plasminogen activator urinary, Plasminogen activator urokinase, Serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1, Serpin E1, Serpin peptidase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1, SERPINE1, u PA, U plasminogen activator, UPA, URK, Urokinase type plasminogen activator

0.5mg/ml (determined by absorbance at 280nm)

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Crippa MP., et al. (2007) Int J Biochem Cell Biol. 39:690-694.;; Kunamneni A., et al. (2008) Recent Pat Cardiovasc Drug Discov. 3:45-58.

> 95% by SDS-PAGE

SDS-PAGE

Human

Enzymes & Proteases

47.4 kDa (419aa)

< 1 EU per 1ug of protein (determined by LAL method)

SNELHQVPSN CDCLNGGTCV SNKYFSNIHW CNCPKKFGGQ HCEIDKSKTC YEGNGHFYRG KASTDTMGRP CLPWNSATVL QQTYHAHRSD ALQLGLGKHN YCRNPDNRRR PWCYVQVGLK PLVQECMVHD CADGKKPSSP PEELKFQCGQ KTLRPRFKII GGEFTTIENQ PWFAAIYRRH RGGSVTYVCG GSLISPCWVI SATHCFIDYP KKEDYIVYLG RSRLNSNTQG EMKFEVENLI LHKDYSADTL AHHNDIALLK IRSKEGRCAQ PSRTIQTICL PSMYNDPQFG TSCEITGFGK ENSTDYLYPE QLKMTVVKLI SHRECQQPHY YGSEVTTKML CAADPQWKTD SCQGDSGGPL VCSLQGRMTL TGIVSWGRGC ALKDKPGVYT RVSHFLPWIR SHTKEENGLA L

His-Tag

Baculovirus

Ser21

Recombinant Protein

P00749

u-Plasminogen Activator, Urokinase, Urokinase-type plasminogen activator, PLAU, ATF, BDPLT5, QPD, u-PA, UPA, URK, Endothelial plasminogen activator inhibitor, PAIPAI 1, PLANH1, Plasminogen activator inhibitor 1, Plasminogen activator urinary, Plasminogen activator urokinase, Serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1, Serpin E1, Serpin peptidase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1, SERPINE1, u PA, U plasminogen activator, UPA, URK, Urokinase type plasminogen activator,ATGP3383-10ug,ATGP3383-20ug,ATGP3383-50ug,ATGP3383-100ug,ATGP3383-250ug,ATGP3383-500ug,ATGP3383-1mg,ATGP3383-10,ATGP3383-20,ATGP3383-50,ATGP3383-100,ATGP3383-250,ATGP3383-500,ATGP3383-1

Hirayama S, et al. Triosephosphate isomerase of Streptococcus pneumoniae is released extracellularly by autolysis and binds to host plasminogen to promote its activation. (FEBS Open Bio. 2022){https://pubmed.ncbi.nlm.nih.gov/35298875/}