Recombinant human DR3/TNFRSF25 protein | NKMAX ATGP3375 product information

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product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human DR3/TNFRSF25 protein

catalog :

ATGP3375

quantity :

10 ug

price :

240 USD

product information

Product Type :

Proteins

Item Name :

Recombinant human DR3/TNFRSF25 protein

Domain :

25-199aa

Catalog number (SKU) :

ATGP3375

NCBI :

NP_003781

Description :

TNFRSF25, also known as Tumor necrosis factor receptor superfamily member 25, is a member of the TNF receptor superfamily that binds to the TNF-like protein TL1A. TNFRSF25 signals are required to exert T helper cell 2 effector function in Th2-polarized CD4 cells and co-stimulate interleukin-13 production by glycosphingolipid-activated NKT cells. Its axis is a novel immune pathway that participates in the pathogenesis of a variety of autoimmune rheumatic diseases. These molecules may be promising therapeutic targets for inflammatory arthritis. Recombinant human TNFRSF25, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Tumor necrosis factor receptor superfamily member 25, TNFRSF25, APO-3, DDR3, DR3, LARD, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LRApo 3, Apo-3, Apo3, Apoptosis inducing receptor, Apoptosis inducing receptor AIR, Apoptosis mediating receptor, Apoptosis mediating receptor DR 3, Apoptosis mediating receptor DR3, Apoptosis mediating receptor TRAMP, Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, DDR 3, DDR3, Death domain receptor 3, Death receptor 3, Death receptor beta, DR 3, LARD, Lymphocyte associated receptor of death, Lymphocyte-associated receptor of death, Protein WSL, Protein WSL-1, TNFRSF 12, TNFRSF 25, TNFRSF12, TNFRSF25, TNR25_HUMAN, TR 3, TR3, TRAMP, Translocating chain association membrane protein, Tumor necrosis factor receptor superfamily member 12, Tumor necrosis factor receptor superfamily member 25, WSL, WSL 1, WSL LR, WSL protein, WSL1, WSL1 protein, WSLLR

Concentration :

0.25mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Slebioda TJ., et al. (2011) Eur J Immunol. 41:2606-2611.;; Fang L., et al. (2008) J Exp Medl. 205:1037-1048.;;

Purity :

> 95% by SDS-PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with Human TL1A/TNFSF15 (CAT# ATGP1049). The ED50 range ≤ 5 ug/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Apoptosis

Molecular Weight :

46.1kDa (417aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human TL1A/TNFSF15 (CAT# ATGP1049) is coated at 10 ug/ml (100 ul/well) can bind Human DR3/TNFRSF25. The ED50 range ≤ 5 ug/ml.

Bioassay Procedure :

QGGTRSP RCDCAGDFHK KIGLFCCRGC PAGHYLKAPC TEPCGNSTCL VCPQDTFLAW ENHHNSECAR CQACDEQASQ VALENCSAVA DTRCGCKPGW FVECQVSQCV SSSPFYCQPC LDCGALHRHT RLLCSRRDTD CGTCLPGFYE HGDGCVSCPT STLGSCPERC AAVCGWRQ

Tag :

hIgG-His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

Q93038

Internal Search Terms :

DR3, TNFRSF25, Tumor necrosis factor receptor superfamily member 25, TNFRSF25, APO-3, DDR3, DR3, LARD, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LRApo 3, Apo-3, Apo3, Apoptosis inducing receptor, Apoptosis inducing receptor AIR, Apoptosis mediating receptor, Apoptosis mediating receptor DR 3, Apoptosis mediating receptor DR3, Apoptosis mediating receptor TRAMP, Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, DDR 3, DDR3, Death domain receptor 3, Death receptor 3, Death receptor beta, DR 3, LARD, Lymphocyte associated receptor of death, Lymphocyte-associated receptor of death, Protein WSL, Protein WSL-1, TNFRSF 12, TNFRSF 25, TNFRSF12, TNFRSF25, TNR25_HUMAN, TR 3, TR3, TRAMP, Translocating chain association membrane protein, Tumor necrosis factor receptor superfamily member 12, Tumor necrosis factor receptor superfamily member 25, WSL, WSL 1, WSL LR, WSL protein, WSL1, WSL1 protein, WSLLR

Size 1 :

10 ug

Price 1 (USD) :

240 USD