Recombinant human CD27 Ligand/CD70 protein | NKMAX ATGP3336 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human CD27 Ligand/CD70 protein

catalog :

ATGP3336

quantity :

10 ug

price :

71 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human CD27 Ligand/CD70 protein

Domain :

39-193aa

Catalog number (SKU) :

ATGP3336

NCBI :

NP_001243.1

Description :

CD70, also known as CD70 antigen, is a transmembrane protein in the TNF receptor superfamily. It functions as a co-stimulatory molecule that supports lymphocyte activation and survival. This protein binds to the transmembrane glycoprotein CD27 ligand/CD70 which is expressed on activated B cells, activated T cells, and dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T cell activation, and thus is proliferation of co-stimulated T cells, as well as the generation of cytolytic T cells. Recombinant human CD70, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

CD70 antigen, CD27L, CD27LG, TNFSF7, tumor necrosis factor superfamily member 7

Concentration :

0.25mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Welten SP., et al. (2013) J. Virol. 87:6851-6865.;; Polak ME., et al. (2012) J. Invest. Dermatol. 132:1636-1644.

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with Human CD27/TNFRSF7 (CAT# ATGP3416).

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Hormones & Cytokines

Molecular Weight :

18.2 kDa (164aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human CD27 Ligand/TNFSF7 is coated at 10 ug/ml (100 ul/well) can bind Human CD27/TNFRSF7 (CAT# ATGP3416) in a Functional ELISA assay.

Amino Acid Sequence :

QRFAQAQ QQLPLESLGW DVAELQLNHT GPQQDPRLYW QGGPALGRSF LHGPELDKGQ LRIHRDGIYM VHIQVTLAIC SSTTASRHHP TTLAVGICSP ASRSISLLRL SFHQGCTIAS QRLTPLARGD TLCTNLTGTL LPSRNTDETF FGVQWVRP

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

P32970

Internal Search Terms :

CD27 Ligand, TNFSF7, CD70 antigen, CD27L, CD27LG, TNFSF7,ATGP3336-10ug,ATGP3336-20ug,ATGP3336-50ug,ATGP3336-100ug,ATGP3336-250ug,ATGP3336-500ug,ATGP3336-1mg,ATGP3336-10,ATGP3336-20,ATGP3336-50,ATGP3336-100,ATGP3336-250,ATGP3336-500,ATGP3336-1

more info or order :

NKMAX product webpage