Recombinant human GITR/TNFRSF18 protein | NKMAX ATGP3319 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human GITR/TNFRSF18 protein

catalog :

ATGP3319

quantity :

10 ug

price :

105 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human GITR/TNFRSF18 protein

Domain :

26-162aa

Catalog number (SKU) :

ATGP3319

NCBI :

NP_004186.1

Description :

TNFRSF18, also known as tumor necrosis factor receptor superfamily member 18 isoform 1, is receptor for TNFSF18. It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. TNFRSF18 mediated NF-kappa-B activation via the TRAF2/NIK pathway. Also, this protein reciprocally stimulated and activate intracellular signals regulating immune functions. In particular, GITR-driven T-cell co-stimulation was found to be the main mechanism by which the GITRL-GITR system contributes to tumor rejection and the development of autoimmune/inflammatory diseases. Recombinant human TNFRSF18, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Tumor necrosis factor receptor superfamily member 18, Activation-inducible TNFR family receptor, Glucocorticoid-induced TNFR-related protein, CD357, AITR, GITR

Concentration :

0.5mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Lacal PM., et al. (2013) J. Pharmacol. Exp. Ther. 347:164-172.;; Xufre C., et al. (2013) Int. Immunol. 25:563-574.;; Shimizu J., et al. (2002) Nat. Immunol. 3:135-142.

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Hormones & Cytokines

Molecular Weight :

41.6 kDa (376aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

QRPTGGPGCG PGRLLLGTGT DARCCRVHTT RCCRDYPGEE CCSEWDCMCV QPEFHCGDPC CTTCRHHPCP PGQGVQSQGK FSFGFQCIDC ASGTFSGGHE GHCKPWTDCT QFGFLTVFPG NKTHNAVCVP GSPPAEP

Tag :

hIgG-His-Tag

Expression System :

Baculovirus

Predicted nterm :

Gln26

Product Type Name :

Recombinant Protein

UniProt No. :

Q9Y5U5

Internal Search Terms :

GITR, TNFRSF18, Tumor necrosis factor receptor superfamily member 18 isoform 1, AITR, CD357, GITR, GITR-D,ATGP3319-10ug,ATGP3319-20ug,ATGP3319-50ug,ATGP3319-100ug,ATGP3319-250ug,ATGP3319-500ug,ATGP3319-1mg,ATGP3319-10,ATGP3319-20,ATGP3319-50,ATGP3319-100,ATGP3319-250,ATGP3319-500,ATGP3319-1

more info or order :

NKMAX product webpage