Recombinant human Carnosine Dipeptidase 1/CNDP1 protein | NKMAX ATGP3227 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Carnosine Dipeptidase 1/CNDP1 protein

catalog :

ATGP3227

quantity :

10 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Carnosine Dipeptidase 1/CNDP1 protein

Domain :

27-507aa

Catalog number (SKU) :

ATGP3227

NCBI :

NP_116038.4

Description :

CNDP1, also known as beta-Ala-His dipeptidase, belongs to the peptidase M20A family. The shortest allelic form (CNDP1 Mannheim) was more common in the absence of nephropathy and was associated with lower serum carnosinase levels. Carnosine inhibited the increased production of fibronectin and collagen type VI in podocytes and the increased production of TGF-beta in mesangial cells. Diabetic patients with the CNDP1 Mannheim variant are less susceptible for nephropathy. Carnosine protects against the adverse effects of high glucose levels on renal cells. Recombinant human CNDP1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Beta-Ala-His dipeptidase, CNDP dipeptidase 1, Carnosine dipeptidase 1, Glutamate carboxypeptidase-like protein 2, Serum carnosinase, CN1, CPGL2, Carnosinase 1

Concentration :

0.25mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Kurashige M., et al. (2013) PLoS ONE 8(1):E54064.;; Ahluwalia TS., et al. (2011) Diabetologia 54(9):2295-2302.

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Signal Transduction

Molecular Weight :

54.9 kDa (489aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

SPSPPPALLE KVFQYIDLHQ DEFVQTLKEW VAIESDSVQP VPRFRQELFR MMAVAADTLQ RLGARVASVD MGPQQLPDGQ SLPIPPVILA ELGSDPTKGT VCFYGHLDVQ PADRGDGWLT DPYVLTEVDG KLYGRGATDN KGPVLAWINA VSAFRALEQD LPVNIKFIIE GMEEAGSVAL EELVEKEKDR FFSGVDYIVI SDNLWISQRK PAITYGTRGN SYFMVEVKCR DQDFHSGTFG GILHEPMADL VALLGSLVDS SGHILVPGIY DEVVPLTEEE INTYKAIHLD LEEYRNSSRV EKFLFDTKEE ILMHLWRYPS LSIHGIEGAF DEPGTKTVIP GRVIGKFSIR LVPHMNVSAV EKQVTRHLED VFSKRNSSNK MVVSMTLGLH PWIANIDDTQ YLAAKRAIRT VFGTEPDMIR DGSTIPIAKM FQEIVHKSVV LIPLGAVDDG EHSQNEKINR WNYIEGTKLF AAFFLEMAQL H

Tag :

His-Tag

Expression System :

Baculovirus

Product Type Name :

Recombinant Protein

UniProt No. :

Q96KN2

Internal Search Terms :

Beta-Ala-His dipeptidase, Carnosine dipeptidase 1, Carnosine Dipeptidase1, CN1, CNDP dipeptidase 1, CNDP1, CPGL2, Glutamate carboxypeptidase-like protein 2, HST2308, ATGP3227-10ug, ATGP3227-20ug, ATGP3227-50ug, ATGP3227-100ug, ATGP3227-250ug, ATGP3227-500ug, ATGP3227-1mg, ATGP3227-010, ATGP3227-020, ATGP3227-050, ATGP3227-100, ATGP3227-250, ATGP3227-500, ATGP3227-01M

more info or order :

NKMAX product webpage