Recombinant human TNFR2/TNFRSF1B protein | NKMAX ATGP3179 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human TNFR2/TNFRSF1B protein

catalog :

ATGP3179

quantity :

10 ug

price :

120 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human TNFR2/TNFRSF1B protein

Domain :

23-257aa

Catalog number (SKU) :

ATGP3179

NCBI :

NP_001057.1

Description :

TNFRSF1B, also known as tumor necrosis factor receptor superfamily member 1B, mediates most of the metabolic effects of TNF-alpha. The receptor isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Further, high plasma levels of TNFRSF1B were significantly associated with increased incidence of coronary heart disease. Recombinant human TNFRSF1B, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor 2, TNF-R2, Tumor necrosis factor receptor type II, TNF-RII, TNFR-II, p75, p80 TNF-alpha receptor, Tumor necrosis factor-binding protein 2, TBP-2, TBPII, CD120b, TNFBR, TNFR80, TNF-R75

Concentration :

1mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Maier O et al., (2013) Biochem. Biophys. Res. Commun. 440(2):336-341.;; Govindaraj C et al., (2013) Clin. Immunol. 149(1):97-110.

Purity :

> 95% by SDS-PAGE

Bioactivity Comment Only :

Measured by its ability to inhibit cytotoxicity using L-929 mouse fibroblast cells in the presence of Human TNF-α. The ED50 range ≤ 0.2 μg/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Hormones & Cytokines

Molecular Weight :

25.9 kDa (241aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human TNFRSF1B inhibit cytotoxicity in the L-929 mouse fibroblast cells in the presence of Human TNF-α. The ED50 range ≤ 0.2 μg/ml.

Amino Acid Sequence :

LPAQVAFTPY APEPGSTCRL REYYDQTAQM CCSKCSPGQH AKVFCTKTSD TVCDSCEDST YTQLWNWVPE CLSCGSRCSS DQVETQACTR EQNRICTCRP GWYCALSKQE GCRLCAPLRK CRPGFGVARP GTETSDVVCK PCAPGTFSNT TSSTDICRPH QICNVVAIPG NASMDAVCTS TSPTRSMAPG AVHLPQPVST RSQHTQPTPE PSTAPSTSFL LPMGPSPPAE GSTGD

Tag :

His-Tag

Expression System :

Baculovirus

Product Type Name :

Recombinant Protein

UniProt No. :

P20333

Internal Search Terms :

TNF RII, TNFRSF1B, TNFRSF1B, CD120b, p75, p75TNFR, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80,ATGP3179-10ug,ATGP3179-20ug,ATGP3179-50ug,ATGP3179-100ug,ATGP3179-250ug,ATGP3179-500ug,ATGP3179-1mg,ATGP3179-10,ATGP3179-20,ATGP3179-50,ATGP3179-100,ATGP3179-250,ATGP3179-500,ATGP3179-1

more info or order :

NKMAX product webpage