Recombinant human IL-10R alpha/IL10RA protein | NKMAX ATGP3074 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human IL-10R alpha/IL10RA protein

catalog :

ATGP3074

quantity :

10 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human IL-10R alpha/IL10RA protein

Domain :

22-235aa

Catalog number (SKU) :

ATGP3074

NCBI :

NP_001549.2

Description :

IL10RA, also known as Interleukin-10 receptor subunit alpha, is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. It has been shown to interact with Interleukin 10 and Janus kinase 1. Recombinant human IL10RA, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Interleukin 10 receptor subunit alpha, IL-10 receptor subunit alpha, IL-10R subunit alpha, IL-10RA, CD210, CDw210a, Interleukin-10 receptor subunit 1, IL-10R subunit 1, IL-10R1, HIL-10R

Concentration :

0.2mg/ml (determined by Bradford assay)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Josephson K, et al. (2001) Acta Crystallogr D Biol Crystallogr. 57(Pt 12):1908-11.;; Usacheva A, et al. (2002) J Immunol. 169(3):1302-8.;;

Purity :

> 85% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Hormones & Cytokines

Molecular Weight :

25.2 kDa (220aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

HGTELPSPPS VWFEAEFFHH ILHWTPIPNQ SESTCYEVAL LRYGIESWNS ISNCSQTLSY DLTAVTLDLY HSNGYRARVR AVDGSRHSNW TVTNTRFSVD EVTLTVGSVN LEIHNGFILG KIQLPRPKMA PANDTYESIF SHFREYEIAI RKVPGNFTFT HKKVKHENFS LLTSGEVGEF CVQVKPSVAS RSNKGMWSKE ECISLTRQYF TVTN

Tag :

His-Tag

Expression System :

Baculovirus

Product Type Name :

Recombinant Protein

UniProt No. :

Q13651

Internal Search Terms :

IL10 R a,ATGP3074-10ug,ATGP3074-20ug,ATGP3074-50ug,ATGP3074-100ug,ATGP3074-250ug,ATGP3074-500ug,ATGP3074-1mg,ATGP3074-10,ATGP3074-20,ATGP3074-50,ATGP3074-100,ATGP3074-250,ATGP3074-500,ATGP3074-1

more info or order :

NKMAX product webpage