protein

Recombinant human LINGO-1 protein

ATGP3011

20 ug

80 USD

Recombinant human LINGO-1 protein

241-337aa

ATGP3011

NP_116197

Lingo1 also known as Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein1. LINGO-1 is primarily expressed in neuronal tissue, and most abundantly in cortex. It has been implicated in the inhibition of axon regeneration through a ternary complex formed with NgR1 (ligand-binding subunit) and p75 (signal transducing subunit). The inhibitory action is achieved through RhoA-GTP upregulation in response to the presence of MOG, MAG or Nogo-66 in the central nervous system. LINGO-1 also inhibits oligodendrocyte precursor differentiation and myelination, by a mechanism that also involves activation of RhoA, but which apparently does not require 75 or NgR1. Recombinant human LINGO1 protein, was expressed in E. coli

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein1, LERN1, LRRN6A, uNQ201

1mg/ml (determined by Bradford assay)

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Mi S., et al (2004). Nat. Neurosci. 7:221-228.;; Mi S., et al (2005). Nat. Neurosci. 8:745-751.

> 90% by SDS-PAGE

SDS-PAGE,Denatured

Human

Neuroscience

15.1 kDa (133aa)

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSLKVL EISHWPYLDT MTPNCLYGLN LTSLSITHCN LTAVPYLAVR HLVYLRFLNL SYNPISTIEG SMLHELLRLQ EIQLVGGQLA VVEPYAFRGL NYL

His-Tag

E.coli

Recombinant Protein

Q96FE5

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