protein

Recombinant human Cathepsin L protein

ATGP2989

20 ug

80 USD

Recombinant human Cathepsin L protein

18-333aa

ATGP2989

NP_001244901.1

CTSL, also known as Cathepsin L1 isoform 1 preproprotein, is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. Recombinant CTSL, fused to His-tag at N-terminus, was expressed in E. coli.

Procathepsin L, Cathepsin L1, Major excreted protein, MEP, CTSL, CTSL1

1mg/ml (determined by Bradford assay)

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Bauer Y, Hess P, et al. (2011). Hypertension. 57(4):795-801.;; Wei DH, Jia XY, et al. (2013). Int J Mol Med. 31(2):400-6.

> 85% by SDS-PAGE

SDS-PAGE, Denatured

Human

Neuroscience

38.3 kDa (339aa)

TLTFDHS LEAQWTKWKA MHNRLYGMNE EGWRRAVWEK NMKMIELHNQ EYREGKHSFT MAMNAFGDMT SEEFRQVMNG FQNRKPRKGK VFQEPLFYEA PRSVDWREKG YVTPVKNQGQ CGSCWAFSAT GALEGQMFRK TGRLISLSEQ NLVDCSGPQG NEGCNGGLMD YAFQYVQDNG GLDSEESYPY EATEESCKYN PKYSVANDTG FVDIPKQEKA LMKAVATVGP ISVAIDAGHE SFLFYKEGIY FEPDCSSEDM DHGVLVVGYG FESTESDNNK YWLVKNSWGE EWGMGGYVKM AKDRRNHCGI ASAASYPTV

His-Tag

E.coli

Recombinant Protein

P07711

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