protein

Recombinant human MKK6 protein

ATGP2942

10 ug

99 USD

Recombinant human MKK6 protein

53-314aa

ATGP2942

NP_002749

MAP2K6 is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, MAP2K6 is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. Recombinant human MAP2K6, fused to His-tag at N-terminus, was expressed in E. coli.

Mitogen-activated protein kinase kinase 6, Mitogen-activated protein kinase kinase 6, MEK6, MKK6, MAPKK6, PRKMK6, SAPKK3

0.25mg/ml (determined by Bradford assay)

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Manning G., et al. (2002) Science 298 (5600): 1912-34;; Pearson G., et al. (2002) Endocr. Rev. 22 (2): 153-83;;

> 85% by SDS-PAGE

SDS-PAGE, Denatured

Human

Cell Cycle

32.0 kDa (383aa)

MLEPIMELGR GAYGVVEKMR HVPSGQIMAV KRIRATVNSQ EQKRLLMDLD ISMRTVDCPF TVTFYGALFR EGDVWICMEL MDTSLDKFYK QVIDKGQTIP EDILGKIAVS IVKALEHLHS KLSVIHRDVK PSNVLINALG QVKMCDFGIS GYLVDEVAKE IDAGCKPYMA PERINPELNQ KGYSVKSDIW SLGITMIELA ILRFPYDSWG TPFQQLKQVV EEPSPQLPAD KFSAEFVDFT SQCLKKNSKE RPTYPELMQH PFF

His-Tag

E.coli

Recombinant Protein

P52564

MKK6, Mitogen-activated protein kinase kinase 6, Mitogen-activated protein kinase kinase 6, MEK6, MKK6, MAPKK6, PRKMK6, SAPKK3,ATGP2942-10ug,ATGP2942-20ug,ATGP2942-50ug,ATGP2942-100ug,ATGP2942-250ug,ATGP2942-500ug,ATGP2942-1mg,ATGP2942-10,ATGP2942-20,ATGP2942-50,ATGP2942-100,ATGP2942-250,ATGP2942-500,ATGP2942-1

Kim DO, et al. TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection. (Int J Mol Sci. 2020){https://pubmed.ncbi.nlm.nih.gov/33327533/}