Recombinant human SIRP alpha/CD172a protein | NKMAX ATGP2811 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human SIRP alpha/CD172a protein

catalog :

ATGP2811

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human SIRP alpha/CD172a protein

Domain :

27-373aa

Catalog number (SKU) :

ATGP2811

NCBI :

NP_542970.1

Description :

SIRPA is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. It was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. Recombinant human SIRPA protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

Tyrosine-protein phosphatase non-receptor type substrate 1, BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol, 1mM DTT

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Timms J.F., Swanson K.D., et al. (1999) Curr. Biol. 9:927-930.

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Neuroscience

Molecular Weight :

40.4 kDa (370aa) confirmed by MALDI-TOF

Amino Acid Sequence :

GVAGEEE LQVIQPDKSV LVAAGETATL RCTATSLIPV GPIQWFRGAG PGRELIYNQK EGHFPRVTTV SDLTKRNNMD FSIRIGNITP ADAGTYYCVK FRKGSPDDVE FKSGAGTELS VRAKPSAPVV SGPAARATPQ HTVSFTCESH GFSPRDITLK WFKNGNELSD FQTNVDPVGE SVSYSIHSTA KVVLTREDVH SQVICEVAHV TLQGDPLRGT ANLSETIRVP PTLEVTQQPV RAENQVNVTC QVRKFYPQRL QLTWLENGNV SRTETASTVT ENKDGTYNWM SWLLVNVSAH RDDVKLTCQV EHDGQPAVSK SHDLKVSAHP KEQGSNTAAE NTGSNERNIY

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P78324

Internal Search Terms :

SIRP a, CD172a, Tyrosine-protein phosphatase non-receptor type substrate 1, BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP,ATGP2811-10ug,ATGP2811-20ug,ATGP2811-50ug,ATGP2811-100ug,ATGP2811-250ug,ATGP2811-500ug,ATGP2811-1mg,ATGP2811-10,ATGP2811-20,ATGP2811-50,ATGP2811-100,ATGP2811-250,ATGP2811-500,ATGP2811-1

more info or order :

NKMAX product webpage