Recombinant HCV E2 protein | NKMAX ATGP2758 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant HCV E2 protein

catalog :

ATGP2758

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant HCV E2 protein

Domain :

482-671aa

Catalog number (SKU) :

ATGP2758

NCBI :

NP_671491

Description :

E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. Recombinant HCV (Hepatitis C Virus) E2 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Alternative Names :

Polyprotein

Concentration :

0.25mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Taylor D.R., et al. (2001) J. Virol. 75:1265-1273;; Kalliampakou K.I., et al. (2015) J. Gen. Virol. 86:1015-1025;;

Purity :

> 80% by SDS-PAGE

Applications :

SDS-PAGE,Denatured

Antigen Species :

HCV

Gene Category :

Virus

Molecular Weight :

25.4 kDa (226aa)

Amino Acid Sequence :

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSERPY CWHYPPRPCG IVPAKSVCGP VYCFTPSPVV VGTTDRSGAP TYSWGANDTD VFVLNNTRPP LGNWFGCTWM NSTGFTKVCG APPCVIGGVG NNTLLCPTDC FRKHPEATYS RCGSGPWITP RCMVDYPYRL WHYPCTINYT IFKVRMYVGG VEHRLEAACN WTRGERCDLE DRDRSELSPL LLSTTQ

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

Internal Search Terms :

HCV, HCV E2, Polyprotein,ATGP2758-10ug,ATGP2758-20ug,ATGP2758-50ug,ATGP2758-100ug,ATGP2758-250ug,ATGP2758-500ug,ATGP2758-1mg,ATGP2758-10,ATGP2758-20,ATGP2758-50,ATGP2758-100,ATGP2758-250,ATGP2758-500,ATGP2758-1

more info or order :

NKMAX product webpage