Recombinant human BCCIP protein | NKMAX ATGP2748 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human BCCIP protein

catalog :

ATGP2748

quantity :

10 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human BCCIP protein

Domain :

1-314aa

Catalog number (SKU) :

ATGP2748

NCBI :

NP_510868

Description :

BCCIP was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Recombinant human BCCIP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

BRCA2 and CDKN1A interacting protein, TOK-1, TOK1

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Luedeke,M., et al. (2009) Cancer Epidemiol. Biomarkers Prev. 18 (11), 3030-3035;; Fan,J., et al. (2009) Cell Cycle 8 (18), 3019-3024;;

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Cell Cycle

Molecular Weight :

38.6 kDa (339aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Amino Acid Sequence :

MGSSHHHHHH SSGLVPRGSH MGSEFMASRS KRRAVESGVP QPPDPPVQRD EEEEKEVENE DEDDDDSDKE KDEEDEVIDE EVNIEFEAYS LSDNDYDGIK KLLQQLFLKA PVNTAELTDL LIQQNHIGSV IKQTDVSEDS NDDMDEDEVF GFISLLNLTE RKGTQCVEQI QELVLRFCEK NCEKSMVEQL DKFLNDTTKP VGLLLSERFI NVPPQIALPM YQQLQKELAG AHRTNKPCGK CYFYLLISKT FVEAGKNNSK KKPSNKKKAA LMFANAEEEF FYEKAILKFN YSVQEESDTC LGGKWSFDDV PMTPLRTVML IPGDKMNEIM DKLKEYLSV

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

Q9P287

Internal Search Terms :

BCCIP, BRCA2 and CDKN1A interacting protein, TOK-1, TOK1,ATGP2748-10ug,ATGP2748-20ug,ATGP2748-50ug,ATGP2748-100ug,ATGP2748-250ug,ATGP2748-500ug,ATGP2748-1mg,ATGP2748-10,ATGP2748-20,ATGP2748-50,ATGP2748-100,ATGP2748-250,ATGP2748-500,ATGP2748-1

more info or order :

NKMAX product webpage