Recombinant human DNMT3L protein | NKMAX ATGP2696 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human DNMT3L protein

catalog :

ATGP2696

quantity :

10 ug

price :

105 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human DNMT3L protein

Domain :

1-386aa

Catalog number (SKU) :

ATGP2696

NCBI :

NP_787063

Description :

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. DNMT3L is a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. It also mediates transcriptional repression through interaction with histone deacetylase 1. Recombinant human DNMT3L protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques

Alternative Names :

DNA (cytosine-5)-methyltransferase 3-like isoform 2, DNA (cytosine-5-)-methyltransferase 3-like

Concentration :

0.25mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Ooi S.K., Qiu C, et al. (2007) Nature 448:714-717;;

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Epigenomics (Transcription & Translation)

Molecular Weight :

46.2 kDa (411aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MAAIP ALDPEAEPSM DVILVGSSEL SSSVSPGTGR DLIAYEVKAN QRNIEDICIC CGSLQVHTQH PLFEGGICAP CKDKFLDALF LYDDDGYQSY CSICCSGETL LICGNPDCTR CYCFECVDSL VGPGTSGKVH AMSNWVCYLC LPSSRSGLLQ RRRKWRSQLK AFYDRESENP LEMFETVPVW RRQPVRVLSL FEDIKKELTS LGFLESGSDP GQLKHVVDVT DTVRKDVEEW GPFDLVYGAT PPLGHTCDRP PSWYLFQFHR LLQYARPKPG SPRPFFWMFV DNLVLNKEDL DVASRFLEME PVTIPDVHGG SLQNAVRVWS NIPAIRSRHW ALVSEEELSL LAQNKQSSKL AAKWPTKLVK NCFLPLREYF KYFSTELTSS L

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

Q9UJW3

Internal Search Terms :

DNMT3L, DNA (cytosine-5)-methyltransferase 3-like isoform 2, DNA (cytosine-5-)-methyltransferase 3-like,ATGP2696-10ug,ATGP2696-20ug,ATGP2696-50ug,ATGP2696-100ug,ATGP2696-250ug,ATGP2696-500ug,ATGP2696-1mg,ATGP2696-10,ATGP2696-20,ATGP2696-50,ATGP2696-100,ATGP2696-250,ATGP2696-500,ATGP2696-1

more info or order :

NKMAX product webpage