Recombinant human HLA-DOB protein | NKMAX ATGP2683 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human HLA-DOB protein

catalog :

ATGP2683

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human HLA-DOB protein

Domain :

27-224aa

Catalog number (SKU) :

ATGP2683

NCBI :

NP_002111

Description :

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Recombinant human HLA-DOB protein, fused to His-tag at N-terminus, was expressed in E. coli.

Alternative Names :

Major histocompatibility complex class II DO beta, Major histocompatibility complex, class II, DO beta, DOB

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Naruse T.K., et al. (2002) Tissue Antigens. 59:512-519;; Beck S., et al. (1996) J. Mol. Biol. 255:1-13;;

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE, Denatured

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

25.2 kDa (222aa)

Amino Acid Sequence :

TDSPED FVIQAKADCY FTNGTEKVQF VVRFIFNLEE YVRFDSDVGM FVALTKLGQP DAEQWNSRLD LLERSRQAVD GVCRHNYRLG APFTVGRKVQ PEVTVYPERT PLLHQHNLLH CSVTGFYPGD IKIKWFLNGQ EERAGVMSTG PIRNGDWTFQ TVVMLEMTPE LGHVYTCLVD HSSLLSPVSV EWRAQSEYSW RK

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P13765

Internal Search Terms :

HLA-DOB, Major histocompatibility complex class II DO beta, Major histocompatibility complex, class II, DO beta, DOB,ATGP2683-10ug,ATGP2683-20ug,ATGP2683-50ug,ATGP2683-100ug,ATGP2683-250ug,ATGP2683-500ug,ATGP2683-1mg,ATGP2683-10,ATGP2683-20,ATGP2683-50,ATGP2683-100,ATGP2683-250,ATGP2683-500,ATGP2683-1

more info or order :

NKMAX product webpage