Recombinant human COPS7A protein | NKMAX ATGP2652 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human COPS7A protein

catalog :

ATGP2652

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human COPS7A protein

Domain :

1-275aa

Catalog number (SKU) :

ATGP2652

NCBI :

NP_001157566

Description :

COPS7A is a component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JuN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JuN promotes and protects degradation by the ubl system, respectively. Recombinant human COPS7A protein, fused to His-tag at N-terminus, was expressed in E. coli.

Alternative Names :

COP9 signalosome complex subunit 7a, COP9 signalosome complex subunit 7a, CSN7A

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Wolf DA, Zhou C, et al. (2003). Nat Cell Biol. 5(12):1029-33.;; Wei N, Tsuge T, et al. (1998). Curr Biol. 8(16):919-22.;;

Purity :

> 80% by SDS-PAGE

Applications :

SDS-PAGE,Denatured

Antigen Species :

Human

Gene Category :

Ubiquitination

Molecular Weight :

32.7 kDa (298aa)

Amino Acid Sequence :

MGSSHHHHHH SSGLVPRGSH MGSMSAEVKV TGQNQEQFLL LAKSAKGAAL ATLIHQVLEA PGVYVFGELL DMPNVRELAE SDFASTFRLL TVFAYGTYAD YLAEARNLPP LTEAQKNKLR HLSVVTLAAK VKCIPYAVLL EALALRNVRQ LEDLVIEAVY ADVLRGSLDQ RNQRLEVDYS IGRDIQRQDL SAIARTLQEW CVGCEVVLSG IEEQVSRANQ HKEQQLGLKQ QIESEVANLK KTIKVTTAAA AAATSQDPEQ HLTELREPAP GTNQRQPSKK ASKGKGLRGS AKIWSKSN

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

Q9UBW8

Internal Search Terms :

COPS7A, COP9 signalosome complex subunit 7a, COP9 signalosome complex subunit 7a, CSN7A,ATGP2652-10ug,ATGP2652-20ug,ATGP2652-50ug,ATGP2652-100ug,ATGP2652-250ug,ATGP2652-500ug,ATGP2652-1mg,ATGP2652-10,ATGP2652-20,ATGP2652-50,ATGP2652-100,ATGP2652-250,ATGP2652-500,ATGP2652-1

more info or order :

NKMAX product webpage