Recombinant human GAD1/GAD67 protein | NKMAX ATGP2642 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human GAD1/GAD67 protein

catalog :

ATGP2642

quantity :

10 ug

price :

105 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human GAD1/GAD67 protein

Domain :

1-224aa

Catalog number (SKU) :

ATGP2642

NCBI :

NP_038473.2

Description :

GAD1 is one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. It is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This protien may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. Recombinant human GAD1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Alternative Names :

Glutamate decarboxylase 1 isoform GAD25, Glutamate decarboxylase 1 (brain, 67kDa), CPSQ1, GAD, SCP

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Chessler S.D., Lernmark A., et al. (2000) J. Biol. Chem. 275:5188-5192.

Purity :

> 85% by SDS-PAGE

Applications :

SDS-PAGE, Denatured

Antigen Species :

Human

Gene Category :

Neuroscience

Molecular Weight :

27.7 kDa (247aa)

Amino Acid Sequence :

MASSTPS SSATSSNAGA DPNTTNLRPT TYDTWCGVAH GCTRKLGLKI CGFLQRTNSL EEKSRLVSAF KERQSSKNLL SCENSDRDAR FRRTETDFSN LFARDLLPAK NGEEQTVQFL LEVVDILLNY VRKTFDRSTK VLDFHHPHQL LEGMEGFNLE LSDHPESLEQ ILVDCRDTLK YGVRTGHPRF FNQLSTGLDI IGLAGEWLTS TANTNMPSDM RECWLLR

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

Q99259

Internal Search Terms :

GAD1, GAD67, Glutamate decarboxylase 1 isoform GAD25, Glutamate decarboxylase 1 (brain, 67kDa), CPSQ1, GAD, SCP,ATGP2642-10ug,ATGP2642-20ug,ATGP2642-50ug,ATGP2642-100ug,ATGP2642-250ug,ATGP2642-500ug,ATGP2642-1mg,ATGP2642-10,ATGP2642-20,ATGP2642-50,ATGP2642-100,ATGP2642-250,ATGP2642-500,ATGP2642-1

more info or order :

NKMAX product webpage