Recombinant human SOCS-3 protein | NKMAX ATGP2589 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human SOCS-3 protein

catalog :

ATGP2589

quantity :

10 ug

price :

105 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human SOCS-3 protein

Domain :

1-225aa

Catalog number (SKU) :

ATGP2589

NCBI :

NP_003946

Description :

SOCS3 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of SOCS3 is induced by various cytokines, including IL6, IL10, and interferon (IFN) -gamma. This protein can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. Recombinant human SOCS3 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Alternative Names :

Suppressor of cytokine signaling 3, CIS3, SSI3, ATOD4, Cish3, SSI-3, SOCS-3, MGC71791

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

McKay BR, Ogborn DI, et al. (2013). Am J Physiol Cell Physiol. 304(8):C717-28.;; Molavi O, Wang P, et al. (2013). Br J Haematol. 161(3):348-56.;;

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE,Denatured

Antigen Species :

Human

Gene Category :

Metabolism

Molecular Weight :

29 kDa (262aa)

Amino Acid Sequence :

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMVT HSKFPAAGMS RPLDTSLRLK TFSSKSEYQL VVNAVRKLQE SGFYWSAVTG GEANLLLSAE PAGTFLIRDS SDQRHFFTLS VKTQSGTKNL RIQCEGGSFS LQSDPRSTQP VPRFDCVLKL VHHYMPPPGA PSFPSPPTEP SSEVPEQPSA QPLPGSPPRR AYYIYSGGEK IPLVLSRPLS SNVATLQHLC RKTVNGHLDS YEKVTQLPGP IREFLDQYDA PL

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

O14543

Internal Search Terms :

SOCS3, Suppressor of cytokine signaling 3, CIS3, SSI3, ATOD4, Cish3, SSI-3, SOCS-3, MGC71791,ATGP2589-10ug,ATGP2589-20ug,ATGP2589-50ug,ATGP2589-100ug,ATGP2589-250ug,ATGP2589-500ug,ATGP2589-1mg,ATGP2589-10,ATGP2589-20,ATGP2589-50,ATGP2589-100,ATGP2589-250,ATGP2589-500,ATGP2589-1

more info or order :

NKMAX product webpage