Recombinant human Siglec-3/CD33 protein | NKMAX ATGP2584 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Siglec-3/CD33 protein

catalog :

ATGP2584

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Siglec-3/CD33 protein

Domain :

18-259aa

Catalog number (SKU) :

ATGP2584

NCBI :

AAH28152

Description :

CD33 is putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase (s) via their SH2 domain (s) that block signal transduction through dephosphorylation of signaling molecules. This protein induces apoptosis in acute myeloid leukemia (in vitro). Recombinant human CD33 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Alternative Names :

SIGLEC-3, SIGLEC3, Sialic acid-binding Ig-like lectin 3, p67, Myeloid cell surface antigen CD33 isoform 1, Myeloid cell surface antigen CD33, FLJ00391, CD33 molecule, CD33

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

ulyanova T., et al. (1999) Eur. J. Immunol. 29:3440-3449;; Vitale C., et al. (2001) Proc. Natl. Acad. Sci. u.S.A. 98:5764-5769;;

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE, Denatured

Antigen Species :

Human

Gene Category :

Stem cell

Molecular Weight :

29.1 kDa (265aa)

Amino Acid Sequence :

DPNFWLQ VQESVTVQEG LCVLVPCTFF HPIPYYDKNS PVHGYWFREG AIISGDSPVA TNKLDQEVQE ETQGRFRLLG DPSRNNCSLS IVDARRRDNG SYFFRMERGS TKYSYKSPQL SVHVTDLTHR PKILIPGTLE PGHSKNLTCS VSWACEQGTP PIFSWLSAAP TSLGPRTTHS SVLIITPRPQ DHGTNLTCQV KFAGAGVTTE RTIQLNVTYV PQNPTTGIFP GDGSGKQETR AGVVH

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P20138

Internal Search Terms :

CD33, CD33 molecule, FLJ00391, p67, SIGLEC-3, SIGLEC3,ATGP2584-10ug,ATGP2584-20ug,ATGP2584-50ug,ATGP2584-100ug,ATGP2584-250ug,ATGP2584-500ug,ATGP2584-1mg,ATGP2584-10,ATGP2584-20,ATGP2584-50,ATGP2584-100,ATGP2584-250,ATGP2584-500,ATGP2584-1

more info or order :

NKMAX product webpage