Recombinant human CD45 protein | NKMAX ATGP2577 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human CD45 protein

catalog :

ATGP2577

quantity :

4 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human CD45 protein

Domain :

1031-1251aa

Catalog number (SKU) :

ATGP2577

NCBI :

NP_002829.3

Description :

PTPRC, also known as CD45, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Recombinant human PTPRC protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

Protein tyrosine phosphatase receptor type isoform 1, Protein tyrosine phosphatase, receptor type, isoform 1, LCA, LY5, B220, CD45, T200, GP180

Concentration :

0.25mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Charbonneau H., et al. (1988) Proc. Natl. Acad. Sci. u.S.A. 85:7182-7186;; Wu L., et al. (2002) Mol. Cell. Biol. 22:2673-2686;;

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Stem cell

Molecular Weight :

29.6 kDa (257aa) confirmed by MALDI-TOF

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

VMIA AQGPLKETIG DFWQMIFQRK VKVIVMLTEL KHGDQEICAQ YWGEGKQTYG DIEVDLKDTD KSSTYTLRVF ELRHSKRKDS RTVYQYQYTN WSVEQLPAEP KELISMIQVV KQKLPQKNSS EGNKHHKSTP LLIHCRDGSQ QTGIFCALLN LLESAETEEV VDIFQVVKAL RKARPGMVST FEQYQFLYDV IASTYPAQNG QVKKNNHQED KIEFDNE

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P08575

Internal Search Terms :

CD45, Protein tyrosine phosphatase receptor type isoform 1, Protein tyrosine phosphatase, receptor type, isoform 1, LCA, LY5, B220, CD45, T200, GP180,ATGP2577-10ug,ATGP2577-20ug,ATGP2577-50ug,ATGP2577-100ug,ATGP2577-250ug,ATGP2577-500ug,ATGP2577-1mg,ATGP2577-10,ATGP2577-20,ATGP2577-50,ATGP2577-100,ATGP2577-250,ATGP2577-500,ATGP2577-1

more info or order :

NKMAX product webpage