Recombinant human Serpin C1/Antithrombin-III protein | NKMAX ATGP2571 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Serpin C1/Antithrombin-III protein

catalog :

ATGP2571

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Serpin C1/Antithrombin-III protein

Domain :

33-464aa

Catalog number (SKU) :

ATGP2571

NCBI :

NP_000479

Description :

Antithrombin-III precursor, also known as SERPINC1, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The inhibitory activity of SERPINC1 is amplified in the presence of heparin. SERPINC1 inhibits Thrombin and Factors IXa, Xa and XIa. Defects in the gene SERPINC1, which encodes for ATIII, can cause ATIII deficiency, an autosomal dominant disease which is a risk factor for hereditary thrombophilia. Recombinant human SERPINC1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Alternative Names :

Antithrombin-III precursor, AT3, AT3D, ATIII, THPH7

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Yeung P K., et al. (2000) IDrugs. 37: 669-673.;; Okajima K., et al. (1995) Am J Hematol. 48: 12-18.;;

Purity :

> 85% by SDS-PAGE

Applications :

SDS-PAGE, Denatured

Antigen Species :

Human

Gene Category :

Cardiovascular

Molecular Weight :

51.4 kDa (455aa)

Amino Acid Sequence :

HGSPVDI CTAKPRDIPM NPMCIYRSPE KKATEDEGSE QKIPEATNRR VWELSKANSR FATTFYQHLA DSKNDNDNIF LSPLSISTAF AMTKLGACND TLQQLMEVFK FDTISEKTSD QIHFFFAKLN CRLYRKANKS SKLVSANRLF GDKSLTFNET YQDISELVYG AKLQPLDFKE NAEQSRAAIN KWVSNKTEGR ITDVIPSEAI NELTVLVLVN TIYFKGLWKS KFSPENTRKE LFYKADGESC SASMMYQEGK FRYRRVAEGT QVLELPFKGD DITMVLILPK PEKSLAKVEK ELTPEVLQEW LDELEEMMLV VHMPRFRIED GFSLKEQLQD MGLVDLFSPE KSKLPGIVAE GRDDLYVSDA FHKAFLEVNE EGSEAAASTA VVIAGRSLNP NRVTFKANRP FLVFIREVPL NTIIFMGRVA NPCVK

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P01008

Internal Search Terms :

Serpin C1, Antithrombin-3, Antithrombin-III precursor, AT3, AT3D, ATIII, THPH7,ATGP2571-10ug,ATGP2571-20ug,ATGP2571-50ug,ATGP2571-100ug,ATGP2571-250ug,ATGP2571-500ug,ATGP2571-1mg,ATGP2571-10,ATGP2571-20,ATGP2571-50,ATGP2571-100,ATGP2571-250,ATGP2571-500,ATGP2571-1

more info or order :

NKMAX product webpage