Recombinant human PSGL-1/CD162 protein | NKMAX ATGP2530 product information

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product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human PSGL-1/CD162 protein

catalog :

ATGP2530

quantity :

20 ug

price :

240 USD

product information

Product type :

Proteins

Item Name :

Recombinant human PSGL-1/CD162 protein

Domain :

42-121aa

Catalog number (SKU) :

ATGP2530

NCBI :

NP_002997

Description :

SELPLG is a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants. Recombinant human SELPLG protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

P-selectin glycoprotein ligand 1 isoform 2 precursor, CD162, CLA, PSGL-1, PSGL1

Concentration :

0.25mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Stubke K, Wicklein D, et al. (2012). Cancer Lett. 321(1):89-99.;; Gong L, Cai Y, et al. (2012). Pathol Oncol Res. 18(4):989-96.;;

Purity :

> 80% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Cardiovascular

Molecular Weight :

10.9 kDa (103aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Bioassay Procedure :

MGSSHHHHHH SSGLVPRGSH MGSQATEYEY LDYDFLPETE PPEMLRNSTD TTPLTGPGTP ESTTVEPAAR RSTGLDAGGA VTELTTELAN MGNLSTDSAA MEI

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

Q14242

Internal Search Terms :

PSGL1, CD162, P-selectin glycoprotein ligand 1 isoform 2 precursor, CD162, CLA, PSGL-1, PSGL1,ATGP2530-10ug,ATGP2530-20ug,ATGP2530-50ug,ATGP2530-100ug,ATGP2530-250ug,ATGP2530-500ug,ATGP2530-1mg,ATGP2530-10,ATGP2530-20,ATGP2530-50,ATGP2530-100,ATGP2530-250,ATGP2530-500,ATGP2530-1

Size 2 :

20 ug

List Price 2 (USD) :

240 USD