Recombinant human Parkin protein | NKMAX ATGP2517 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Parkin protein

catalog :

ATGP2517

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Parkin protein

Domain :

1-465aa

Catalog number (SKU) :

ATGP2517

NCBI :

NP_004553.2

Description :

The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. Recombinant human PARK2 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Alternative Names :

E3 ubiquitin-protein ligase parkin, AR-JP, LPRS2, PDJ, PRKN

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Imai Y., et al. (2000) J. Biol. Chem. 275:35661-35664;; Shimura H., et al. (2000) Nat. Genet. 25:302-305;;

Purity :

> 80% by SDS-PAGE

Applications :

SDS-PAGE,Denatured

Antigen Species :

Human

Gene Category :

Metabolism

Molecular Weight :

53.8 kDa (485aa)

Amino Acid Sequence :

MGSSHHHHHH SSGLVPRGSH MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL RNDWTVQNCD LDQQSIVHIV QRPWRKGQEM NATGGDDPRN AAGGCEREPQ SLTRVDLSSS VLPGDSVGLA VILHTDSRKD SPPAGSPAGR SIYNSFYVYC KGPCQRVQPG KLRVQCSTCR QATLTLTQGP SCWDDVLIPN RMSGECQSPH CPGTSAEFFF KCGAHPTSDK ETSVALHLIA TNSRNITCIT CTDVRSPVLV FQCNSRHVIC LDCFHLYCVT RLNDRQFVHD PQLGYSLPCV AGCPNSLIKE LHHFRILGEE QYNRYQQYGA EECVLQMGGV LCPRPGCGAG LLPEPDQRKV TCEGGNGLGC GFAFCRECKE AYHEGECSAV FEASGTTTQA YRVDERAAEQ ARWEAASKET IKKTTKPCPR CHVPVEKNGG CMHMKCPQPQ CRLEWCWNCG CEWNRVCMGD HWFDV

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

O60260

Internal Search Terms :

Parkin, E3 ubiquitin-protein ligase parkin, AR-JP, LPRS2, PDJ, PRKN,ATGP2517-10ug,ATGP2517-20ug,ATGP2517-50ug,ATGP2517-100ug,ATGP2517-250ug,ATGP2517-500ug,ATGP2517-1mg,ATGP2517-10,ATGP2517-20,ATGP2517-50,ATGP2517-100,ATGP2517-250,ATGP2517-500,ATGP2517-1

more info or order :

NKMAX product webpage