Recombinant human PABPN1 protein | NKMAX ATGP2500 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human PABPN1 protein

catalog :

ATGP2500

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human PABPN1 protein

Domain :

119-306aa

Catalog number (SKU) :

ATGP2500

NCBI :

NP_004634

Description :

PABPN1 is an abundant nuclear protein that binds with high affinity to nascent poly (A) tails. The protein is required for progressive and efficient polymerization of poly (A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly (A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly (A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. Recombinant human PABPN1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Alternative Names :

Polyadenylate-binding protein 2, OPMD, PAB2, PABII, PABP-2, PABP2

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Fan X., et al. (2001) Hum. Mol. Genet. 10:2341-2351.

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE,Denatured

Antigen Species :

Human

Gene Category :

Epigenomics (Transcription & Translation)

Molecular Weight :

23.8 kDa (211aa)

Amino Acid Sequence :

MGSSHHHHHH SSGLVPRGSH MGSLEAIKAR VREMEEEAEK LKELQNEVEK QMNMSPPPGN AGPVIMSIEE KMEADARSIY VGNVDYGATA EELEAHFHGC GSVNRVTILC DKFSGHPKGF AYIEFSDKES VRTSLALDES LFRGRQIKVI PKRTNRPGIS TTDRGFPRAR YRARTTNYNS SRSRFYSGFN SRPRGRVYRG RARATSWYSP Y

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

Q86U42

Internal Search Terms :

PABPN1, Polyadenylate-binding protein 2, OPMD, PAB2, PABII, PABP-2, PABP2,ATGP2500-10ug,ATGP2500-20ug,ATGP2500-50ug,ATGP2500-100ug,ATGP2500-250ug,ATGP2500-500ug,ATGP2500-1mg,ATGP2500-10,ATGP2500-20,ATGP2500-50,ATGP2500-100,ATGP2500-250,ATGP2500-500,ATGP2500-1

more info or order :

NKMAX product webpage