Recombinant human Dynactin Subunit 2/DCTN2 protein | NKMAX ATGP2490 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Dynactin Subunit 2/DCTN2 protein

catalog :

ATGP2490

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Dynactin Subunit 2/DCTN2 protein

Domain :

1-406aa

Catalog number (SKU) :

ATGP2490

NCBI :

NP_006391.1

Description :

DCTN2 is a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Recombinant human DCTN2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

Dynactin subunit 2 isoform 1, Dynactin subunit 2 isoform 1, Dynactin 2 (p50), DCTN50, DYNAMITIN, RBP50

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.15M NaCl, 1mM DTT

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Echeverri C.J., Paschal B.M. et al. (1996), J. Cell Biol. 132:617-633

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Signal Transduction

Molecular Weight :

47.2 kDa (429aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MADPKYA DLPGIARNEP DVYETSDLPE DDQAEFDAFA QELEELTSTS VEHIIVNPNA AYDKFKDKRV GTKGLDFSDR IGKTKRTGYE SGEYEMLGEG LGVKETPQQK YQRLLHEVQE LTTEVEKIKT TVKESATEEK LTPVLLAKQL AALKQQLVAS HLEKLLGPDA AINLTDPDGA LAKRLLLQLE ATKNSKGGSG GKTTGTPPDS SLVTYELHSR PEQDKFSQAA KVAELEKRLT ELETAVRCDQ DAQNPLSAGL QGACLMETVE LLQAKVSALD LAVLDQVEAR LQSVLGKVNE IAKHKASVED ADTQSKVHQL YETIQRWSPI ASTLPELVQR LVTIKQLHEQ AMQFGQLLTH LDTTQQMIAN SLKDNTTLLT QVQTTMRENL ATVEGNFASI DERMKKLGK

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

Q13561

Internal Search Terms :

Dynactin Subunit2, DCTN2, Dynactin subunit 2 isoform 1, Dynactin subunit 2 isoform 1, Dynactin 2 (p50), DCTN50, DYNAMITIN, RBP50,ATGP2490-10ug,ATGP2490-20ug,ATGP2490-50ug,ATGP2490-100ug,ATGP2490-250ug,ATGP2490-500ug,ATGP2490-1mg,ATGP2490-10,ATGP2490-20,ATGP2490-50,ATGP2490-100,ATGP2490-250,ATGP2490-500,ATGP2490-1

more info or order :

NKMAX product webpage