Recombinant human Myelin Basic Protein/MBP protein | NKMAX ATGP2348 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Myelin Basic Protein/MBP protein

catalog :

ATGP2348

quantity :

20 ug

price :

105 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Myelin Basic Protein/MBP protein

Domain :

1-197aa

Catalog number (SKU) :

ATGP2348

NCBI :

NP_001020271.1

Description :

MBP is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Recombinant human MBP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

myelin basic protein

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol,

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Nye S.H., et al (1995). Mol. Immunol. 32:1131-1141;; Pribyl T.M., et al (1993). Proc. Natl. Acad. Sci. u.S.A. 90:10695-10699;;

Purity :

> 85% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Neuroscience

Molecular Weight :

23.9 kDa (220aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MGNHAGK RELNAEKAST NSETNRGESE KKRNLGELSR TTSEDNEVFG EADANQNNGT SSQDTAVTDS KRTADPKNAW QDAHPADPGS RPHLIRLFSR DAPGREDNTF KDRPSESDEL QTIQEDSAAT SESLDVMASQ KRPSQRHGSK YLATASTMDH ARHGFLPRHR DTGILDSIGR FFGGDRGAPK RGSGKVSSEE

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P02686

Internal Search Terms :

MBP, myelin basic protein,ATGP2348-10ug,ATGP2348-20ug,ATGP2348-50ug,ATGP2348-100ug,ATGP2348-250ug,ATGP2348-500ug,ATGP2348-1mg,ATGP2348-10,ATGP2348-20,ATGP2348-50,ATGP2348-100,ATGP2348-250,ATGP2348-500,ATGP2348-1

more info or order :

NKMAX product webpage