product summary
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company name :
NKMAX
product type :
protein
product name :
Recombinant human Norrin protein
catalog :
ATGP2290
quantity :
10 ug
price :
80 USD
more info or order :
product information
Product Type :
Proteins
Item Name :
Recombinant human Norrin protein
Domain :
25-133aa
Catalog number (SKU) :
ATGP2290
NCBI :
NP_000257.1
Description :
Norrin precursor, also known as NDP, is a secreted regulatory protein. It activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. This protein plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. It may be involved in a pathway that regulates neural cell differentiation and proliferation. Recombinant human NDP protein, fused to His-tag at N-terminus, was expressed in E. coli.
Alternative Names :
Norrin, EVR2, FEVR, ND, NDP
Concentration :
0.5mg/ml (determined by Bradford assay)
Formulation :
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Storage :
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
General References :
Luhmann u F., et al. (2005) Invest Pothalmol Vis Sci. 46:3372-3382.;; Luhmann u F., et al. (2005) Genesis. 42:253-262
Purity :
> 80% by SDS-PAGE
Applications :
SDS-PAGE, Denatured
Antigen Species :
Human
Gene Category :
Neuroscience
Molecular Weight :
14.8 kDa (132aa)
Amino Acid Sequence :
KTDSSFI MDSDPRRCMR HHYVDSISHP LYKCSSKMVL LARCEGHCSQ ASRSEPLVSF STVLKQPFRS SCHCCRPQTS KLKALRLRCS GGMRLTATYR YILSCHCEEC NS
Tag :
His-Tag
Expression System :
E.coli
Product Type Name :
Recombinant Protein
UniProt No. :
Q00604
Internal Search Terms :
Norrin, Norrin, EVR2, FEVR, ND,ATGP2290-10ug,ATGP2290-20ug,ATGP2290-50ug,ATGP2290-100ug,ATGP2290-250ug,ATGP2290-500ug,ATGP2290-1mg,ATGP2290-10,ATGP2290-20,ATGP2290-50,ATGP2290-100,ATGP2290-250,ATGP2290-500,ATGP2290-1
more info or order :
company information
NKMAX
SNUH Health Care Innovation Park 6F
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
https://www.nkmaxbio.com172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
82-31-8017-8114
headquarters: South Korea
NKMAX Co. Ltd. is a biotech company that manufactures and supplies a unique line of quality proteins and antibodies worldwide to both researchers and retailers.