Recombinant human RFXANK protein | NKMAX ATGP2188 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human RFXANK protein

catalog :

ATGP2188

quantity :

4 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human RFXANK protein

Domain :

1-237aa

Catalog number (SKU) :

ATGP2188

NCBI :

NP_604389

Description :

RFXANK, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity. Recombinant human RFXANK protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

DNA-binding protein RFXANK isoform b, ANKRA1, BLS, F14150_1, RFX-B

Concentration :

0.25mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Krawczyk M, Masternak K, et al. (2005). Mol Cell Biol. 25(19):8607-18.

Purity :

> 85% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

28 kDa (260aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MELTQPA EDLIQTQQTP ASELGDPEDP GEEAADGSDT VVLSLFPCTP EPVNPEPDAS VSSPQGSSLK HSTTLTNRQR GNEVSALPAT LDCDNLVNKP DERGFTPLIW ASAFGEIETV RFLLEWGADP HILAKERESA LSLASTGGYT DIVGLLLERD VDINIYDWNG GTPLLYAVRG NHVKCVEALL ARGADLTTEA DSGYTPMDLA VALGYRKVQQ VIENHILKLF QSNLVPADPE

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

O14593

Internal Search Terms :

RFXANK, DNA-binding protein RFXANK isoform b, ANKRA1, BLS, F14150_1, RFX-B,ATGP2188-10ug,ATGP2188-20ug,ATGP2188-50ug,ATGP2188-100ug,ATGP2188-250ug,ATGP2188-500ug,ATGP2188-1mg,ATGP2188-10,ATGP2188-20,ATGP2188-50,ATGP2188-100,ATGP2188-250,ATGP2188-500,ATGP2188-1

more info or order :

NKMAX product webpage