Recombinant human RNASEH2A protein | NKMAX ATGP2138 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human RNASEH2A protein

catalog :

ATGP2138

quantity :

20 ug

price :

105 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human RNASEH2A protein

Domain :

1-299aa

Catalog number (SKU) :

ATGP2138

NCBI :

NP_006388

Description :

Ribonuclease H2 subunit A, also known as RNASEH2A, belongs to the RNase HII family and eukaryotic subfamily. Localized to the nucleus, RNASEH2A mediates the removal of Okazaki fragment RNA primers that are present on the lagging strand during DNA replication. RNASEH2A catalyzes the endonucleolytic cleavage of RNA to a 5'-phosphomonoester and is able to bind magnesium or manganese as cofactors. Defects in RNASEH2A are the cause of Aicardi-Goutieres syndrome type 4 (AGS4). Recombinant human RNASEH2A protein, fused to His-tag at N-terminus, was expressed in E. coli

Alternative Names :

Ribonuclease H2 subunit A, AGS4, JuNB, RNASEHI, RNHIA, RNHL

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Frank P., et al. (1998) Proc Natl Acad Sci uSA. 95:12872-12877.;; Bayliss C D., et al. (2005) Nucleic Acads Res. 33:400-408.

Purity :

> 85% by SDS-PAGE

Applications :

SDS-PAGE,Denatured

Antigen Species :

Human

Gene Category :

Epigenomics (Transcription & Translation)

Molecular Weight :

35.8 kDa (322aa)

Amino Acid Sequence :

MGSSHHHHHH SSGLVPRGSH MGSMDLSELE RDNTGRCRLS SPVPAVCRKE PCVLGVDEAG RGPVLGPMVY AICYCPLPRL ADLEALKVAD SKTLLESERE RLFAKMEDTD FVGWALDVLS PNLISTSMLG RVKYNLNSLS HDTATGLIQY ALDQGVNVTQ VFVDTVGMPE TYQARLQQSF PGIEVTVKAK ADALYPVVSA ASICAKVARD QAVKKWQFVE KLQDLDTDYG SGYPNDPKTK AWLKEHVEPV FGFPQFVRFS WRTAQTILEK EAEDVIWEDS ASENQEGLRK ITSYFLNEGS QARPRSSHRY FLERGLESAT SL

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

O75792

Internal Search Terms :

RNASEH2A, Ribonuclease H2 subunit A, AGS4, JuNB, RNASEHI, RNHIA, RNHL,ATGP2138-10ug,ATGP2138-20ug,ATGP2138-50ug,ATGP2138-100ug,ATGP2138-250ug,ATGP2138-500ug,ATGP2138-1mg,ATGP2138-10,ATGP2138-20,ATGP2138-50,ATGP2138-100,ATGP2138-250,ATGP2138-500,ATGP2138-1

more info or order :

NKMAX product webpage