Recombinant human DKK1 protein | NKMAX ATGP2070 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human DKK1 protein

catalog :

ATGP2070

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human DKK1 protein

Domain :

32-266aa

Catalog number (SKU) :

ATGP2070

NCBI :

NP_036374

Description :

Dickkopf-related protein 1, also known as DKK1, antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Recombinant human DKK1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Alternative Names :

Dickkopf WNT signaling pathway inhibitor 1, Dickkopf-related protein 1, Dickkopf-1, Dkk-1, SK

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Ahn V.E., et al. (2011) Dev. Cell. 21:862-873;; Haniu M., et al. (2011) Protein Sci. 20:1802-1813;;

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE, Denatured

Antigen Species :

Human

Gene Category :

Development

Molecular Weight :

28.2 kDa (258aa)

Amino Acid Sequence :

MGSSHHHHHH SSGLVPRGSH MGSTLNSVLN SNAIKNLPPP LGGAAGHPGS AVSAAPGILY PGGNKYQTID NYQPYPCAED EECGTDEYCA SPTRGGDAGV QICLACRKRR KRCMRHAMCC PGNYCKNGIC VSSDQNHFRG EIEETITESF GNDHSTLDGY SRRTTLSSKM YHTKGQEGSV CLRSSDCASG LCCARHFWSK ICKPVLKEGQ VCTKHRRKGS HGLEIFQRCY CGEGLSCRIQ KDHHQASNSS RLHTCQRH

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

O94907

Internal Search Terms :

Dickkopf 1, Dickkopf 1 homolog, Dickkopf 1 like, Dickkopf homolog 1, Dickkopf related protein 1, Dickkopf-1, Dickkopf-related protein 1, Dickkopf-related protein 1 Dickkopf 1, DKK 1, DKK1, DKK-1, hDkk 1, hDkk1, hDkk-1, SK, Xenopus laevis, ATGP2070-10ug, ATGP2070-20ug, ATGP2070-50ug, ATGP2070-100ug, ATGP2070-250ug, ATGP2070-500ug, ATGP2070-1mg, ATGP2070-010, ATGP2070-020, ATGP2070-050, ATGP2070-100, ATGP2070-250, ATGP2070-500, ATGP2070-01M

more info or order :

NKMAX product webpage