Recombinant human PIM1 protein | NKMAX ATGP1997 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human PIM1 protein

catalog :

ATGP1997

quantity :

10 ug

price :

105 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human PIM1 protein

Domain :

38-290aa

Catalog number (SKU) :

ATGP1997

NCBI :

NP_002639.1

Description :

PIM1 belongs to the Ser/Thr protein kinase family, and PIM subfamily. This protein is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AuG (CuG) and downstream AuG codons. Recombinant human Pim1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

Non-specific serine/threonine protein kinase, PIM

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Koike N., et al. (2000) FEBS Lett. 467:17-21;; Ionov Y., et al. (2003) Anticancer Res. 23:167-178;;

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Cancer

Molecular Weight :

31.4 kDa (274aa) confirmed by MALDI-TOF

Amino Acid Sequence :

YQVGPLLGS GGFGSVYSGI RVSDNLPVAI KHVEKDRISD WGELPNGTRV PMEVVLLKKV SSGFSGVIRL LDWFERPDSF VLILERPEPV QDLFDFITER GALQEELARS FFWQVLEAVR HCHNCGVLHR DIKDENILID LNRGELKLID FGSGALLKDT VYTDFDGTRV YSPPEWIRYH RYHGRSAAVW SLGILLYDMV CGDIPFEHDE EIIRGQVFFR QRVSSECQHL IRWCLALRPS DRPTFEEIQN HPWM

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P11309

Internal Search Terms :

PIM1, Non-specific serine/threonine protein kinase, PIM,ATGP1997-10ug,ATGP1997-20ug,ATGP1997-50ug,ATGP1997-100ug,ATGP1997-250ug,ATGP1997-500ug,ATGP1997-1mg,ATGP1997-10,ATGP1997-20,ATGP1997-50,ATGP1997-100,ATGP1997-250,ATGP1997-500,ATGP1997-1

more info or order :

NKMAX product webpage