protein

Recombinant human delta Sarcoglycan/SGCD protein

ATGP1980

20 ug

80 USD

Recombinant human delta Sarcoglycan/SGCD protein

57-289aa

ATGP1980

NP_001121681

SGCD is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. The mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed. In melanocytic cells SGCD gene expression may be regulated by MITF. Recombinant human SGCD protein, fused to His-tag at N-terminus, was expressed in E. coli.

Delta-sarcoglycan, 35DAG, CMD1L, DAGD, SG-delta, SGCDP, SGD, LGMD2F, Delta-SG

1mg/ml (determined by Bradford assay)

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Sylvius N, Duboscq-Bidot L, et al. (2003). Am J Med Genet A. 120A(1):8-12.

> 85% by SDS-PAGE

SDS-PAGE, Denatured

Human

Cytoskeleton

28.1 kDa (257aa)

KVMNFT IDGMGNLRIT EKGLKLEGDS EFLQPLYAKE IQSRPGNALY FKSARNVTVN ILNDQTKVLT QLITGPKAVE AYGKKFEVKT VSGKLLFSAD NNEVVVGAER LRVLGAEGTV FPKSIETPNV RADPFKELRL ESPTRSLVME APKGVEINAE AGNMEATCRT ELRLESKDGE IKLDAAKIRL PRLPHGSYTP TGTRQKVFEI CVCANGRLFL SQAGAGSTCQ INTSVCL

His-Tag

E.coli

Recombinant Protein

Q92629

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