Recombinant human MVK protein | NKMAX ATGP1933 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human MVK protein

catalog :

ATGP1933

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human MVK protein

Domain :

1-396aa

Catalog number (SKU) :

ATGP1933

NCBI :

NP_001107657.1

Description :

Mevalonate kinase, also known as MVK, belongs to the GHMP kinase family. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Recombinant human MVK protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

Mevalonate kinase, LRBP, MK, MVLK

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Cuisset L., et al. (2001) Eur. J. Hum. Genet. 9:260-266;; D'Osualdo A., et al. (2005) Eur. J. Hum. Genet. 13:314-320

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Metabolism

Molecular Weight :

44.8 kDa (419aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MLSEVLL VSAPGKVILH GEHAVVHGKV ALAVSLNLRT FLRLQPHSNG KVDLSLPNIG IKRAWDVARL QSLDTSFLEQ GDVTTPTSEQ VEKLKEVAGL PDDCAVTERL AVLAFLYLYL SICRKQRALP SLDIVVWSEL PPGAGLGSSA AYSVCLAAAL LTVCEEIPNP LKDGDCVNRW TKEDLELINK WAFQGERMIH GNPSGVDNAV STWGGALRYH QGKISSLKRS PALQILLTNT KVPRNTRALV AGVRNRLLKF PEIVAPLLTS IDAISLECER VLGEMGEAPA PEQYLVLEEL IDMNQHHLNA LGVGHASLDQ LCQVTRARGL HSKLTGAGGG GCGITLLKPG LEQPEVEATK QALTSCGFDC LETSIGAPGV SIHSATSLDS RVQQALDGL

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

Q03426

Internal Search Terms :

MVK, Mevalonate kinase, LRBP, MK, MVLK,ATGP1933-10ug,ATGP1933-20ug,ATGP1933-50ug,ATGP1933-100ug,ATGP1933-250ug,ATGP1933-500ug,ATGP1933-1mg,ATGP1933-10,ATGP1933-20,ATGP1933-50,ATGP1933-100,ATGP1933-250,ATGP1933-500,ATGP1933-1

more info or order :

NKMAX product webpage