Recombinant human LMP7/PSMB8 protein | NKMAX ATGP1830 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human LMP7/PSMB8 protein

catalog :

ATGP1830

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human LMP7/PSMB8 protein

Domain :

73-276aa

Catalog number (SKU) :

ATGP1830

NCBI :

NP_683720.2

Description :

PSMB8, also known as LMP7, belongs to the peptidase T1B family. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMB8 is located in the class II region of the MHC (major histocompatibility complex). Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. This protein acts as a major component of interferon gamma-induced sensitivity. It plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. Recombinant human PSMB8 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Alternative Names :

proteasome (prosome macropain) subunit beta type 8, proteasome (prosome, macropain) subunit, beta type, 8, D6S216, D6S216E, LMP7, MGC1491, PSMB5i

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Muchamuel T., et al. (2009) Nat. Med. 15:781-787;; Kitamura A., et al. (2011) J. Clin. Invest. 121:4150-4160;;

Purity :

> 85% by SDS-PAGE

Applications :

SDS-PAGE, Denatured

Antigen Species :

Human

Gene Category :

Ubiquitination

Molecular Weight :

25.4 kDa (229aa)

Amino Acid Sequence :

TTTLA FKFQHGVIAA VDSRASAGSY ISALRVNKVI EINPYLLGTM SGCAADCQYW ERLLAKECRL YYLRNGERIS VSAASKLLSN MMCQYRGMGL SMGSMICGWD KKGPGLYYVD EHGTRLSGNM FSTGSGNTYA YGVMDSGYRP NLSPEEAYDL GRRAIAYATH RDSYSGGVVN MYHMKEDGWV KVESTDVSDL LHQYREANQ

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P28062

Internal Search Terms :

LMP7, PSMB8, proteasome (prosome macropain) subunit beta type 8, proteasome (prosome, macropain) subunit, beta type, 8, D6S216, D6S216E, LMP7, MGC1491, PSMB5i,ATGP1830-10ug,ATGP1830-20ug,ATGP1830-50ug,ATGP1830-100ug,ATGP1830-250ug,ATGP1830-500ug,ATGP1830-1mg,ATGP1830-10,ATGP1830-20,ATGP1830-50,ATGP1830-100,ATGP1830-250,ATGP1830-500,ATGP1830-1

more info or order :

NKMAX product webpage