Recombinant human Beclin 1/BECN1 protein | NKMAX ATGP1816 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Beclin 1/BECN1 protein

catalog :

ATGP1816

quantity :

4 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Beclin 1/BECN1 protein

Domain :

1-450aa

Catalog number (SKU) :

ATGP1816

NCBI :

NP_003757.1

Description :

BECN1, also as known as Beclin-1 and autophagy-related gene (Atg) 6, belongs to the beclin family. This protein plays a central role in autophagy. Beclin-1 and its binding partner class III phosphoinositide 3-kinase (PI3K), also named Vps34, are required for the initiation of the formation of the autophagasome in autophagy. Also it required for the abcission step of cytokinesis. BECN1 plays a role in antiviral host defense. Recombinant human BECN1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by conventional column chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.

Alternative Names :

Beclin 1, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197, Beclin 1 autophagy related, ATG6, ATG6 autophagy related 6 homolog, VPS30

Concentration :

0.25mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.5) containing 0.1M NaCl, 10% glycerol,1mM DTT

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Sagona A.P., et al. (2010) Nat. Cell Biol. 12:362-371;; Itakura E., et al. (2008) Mol. Biol. Cell 19:5360-5372;;

Purity :

> 85% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Metabolism

Molecular Weight :

54.1 kDa (470aa)

Amino Acid Sequence :

MEGSKTSNNS TMQVSFVCQR CSQPLKLDTS FKILDRVTIQ ELTAPLLTTA QAKPGETQEE ETNSGEEPFI ETPRQDGVSR RFIPPARMMS TESANSFTLI GEASDGGTME NLSRRLKVTG DLFDIMSGQT DVDHPLCEEC TDTLLDQLDT QLNVTENECQ NYKRCLEILE QMNEDDSEQL QMELKELALE EERLIQELED VEKNRKIVAE NLEKVQAEAE RLDQEEAQYQ REYSEFKRQQ LELDDELKSV ENQMRYAQTQ LDKLKKTNVF NATFHIWHSG QFGTINNFRL GRLPSVPVEW NEINAAWGQT VLLLHALANK MGLKFQRYRL VPYGNHSYLE SLTDKSKELP LYCSGGLRFF WDNKFDHAMV AFLDCVQQFK EEVEKGETRF CLPYRMDVEK GKIEDTGGSG GSYSIKTQFN SEEQWTKALK FMLTNLKWGL AWVSSQFYNK

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

Q14457

Internal Search Terms :

Beclin1, beclin 1, ATG6, beclin1, VPS30,ATGP1816-10ug,ATGP1816-20ug,ATGP1816-50ug,ATGP1816-100ug,ATGP1816-250ug,ATGP1816-500ug,ATGP1816-1mg,ATGP1816-10,ATGP1816-20,ATGP1816-50,ATGP1816-100,ATGP1816-250,ATGP1816-500,ATGP1816-1

more info or order :

NKMAX product webpage