Recombinant human TDG protein | NKMAX ATGP1705 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human TDG protein

catalog :

ATGP1705

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human TDG protein

Domain :

1-410aa

Catalog number (SKU) :

ATGP1705

NCBI :

AAH37557

Description :

Thymine-DNA glycosylase, also known as TDG, belongs to the TDG/mug DNA glycosylase family. TDG is a nuclear protein which corrects G/T mismatches to G/C pairs by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired thymin. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. Recombinant human TDG protein, fused to His-tag at N-terminus, was expressed in E. coli

Alternative Names :

Thymine-DNA glycosylase, G/T mismatch-specific thymine DNA glycosylase,

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4 urea, 10% glycerol, 0.1M NaCl

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

um S., et al. (1998) J Biol Chem. 273:20728-20736.;; Hardeland u., et al. (2002) EMBO J. 21:1456-1464.

Purity :

> 85% by SDS-PAGE

Applications :

SDS-PAGE,Denatured

Antigen Species :

Human

Gene Category :

Epigenomics (Transcription & Translation)

Molecular Weight :

48.4 kDa (433aa)

Amino Acid Sequence :

MEAENAG SYSLQQAQAF YTFPFQQLMA EAPNMAVVNE QQMPEEVPAP APAQEPVQEA PKGRKRKPRT TEPKQPVEPK KPVESKKSGK SAKSKEKQEK ITDTFKVKRK VDRFNGVSEA ELLTKTLPDI LTFNLDIVII GINPGLMAAY KGHHYPGPGN HFWKCLFMSG LSEVQLNHMD DHTLPGKYGI GFTNMVERTT PGSKDLSSKE FREGGRILVQ KLQKYQPRIA VFNGKCIYEI FSKEVFGVKV KNLEFGLQPH KIPDTETLCY GMPSSSARCA QFPRAQDKVH YYIKLKDLRD QLKGIERNMD VQEVQYTFDL QLAQEDAKKM AVKEEKYDPG YEAAYGGAYG ENPCSSEPCG FSSNGLIESV ELRGESAFSG IPNGQWMTQS FTDQIPSFSN HCGTQEQEEE SHA

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

Q13569

Internal Search Terms :

TDG,ATGP1705-10ug,ATGP1705-20ug,ATGP1705-50ug,ATGP1705-100ug,ATGP1705-250ug,ATGP1705-500ug,ATGP1705-1mg,ATGP1705-10,ATGP1705-20,ATGP1705-50,ATGP1705-100,ATGP1705-250,ATGP1705-500,ATGP1705-1

more info or order :

NKMAX product webpage