Recombinant human TIMP-2 protein | NKMAX ATGP1687 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human TIMP-2 protein

catalog :

ATGP1687

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human TIMP-2 protein

Domain :

27-220aa

Catalog number (SKU) :

ATGP1687

NCBI :

NP_003246

Description :

TIMP2 is a natural inhibitor of the matrix metalloproteinases, a group of peptidases involved in of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, this protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, TIMP2 may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular. Recombinant human TIMP2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

TIMP metallopeptidase inhibitor 2, CSC-21K, CSC21K

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Bahudhanapati,H., et al. (2011) J. Biol. Chem. 286 (36), 31761-31770;; Seo,D.W.,et al. (2011) Peptides 32 (9), 1840-1848

Purity :

> 85% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Signal Transduction

Molecular Weight :

26.1 kDa (232aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMCS CSPVHPQQAF CNADVVIRAK AVSEKEVDSG NDIYGNPIKR IQYEIKQIKM FKGPEKDIEF IYTAPSSAVC GVSLDVGGKK EYLIAGKAEG DGKMHITLCD FIVPWDTLST TQKKSLNHRY QMGCECKITR CPMIPCYISS PDECLWMDWV TEKNINGHQA KFFACIKRSD GSCAWYRGAA PPKQEFLDIE DP

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P16035

Internal Search Terms :

TIMP2, TIMP metallopeptidase inhibitor 2, CSC-21K, CSC21K,ATGP1687-10ug,ATGP1687-20ug,ATGP1687-50ug,ATGP1687-100ug,ATGP1687-250ug,ATGP1687-500ug,ATGP1687-1mg,ATGP1687-10,ATGP1687-20,ATGP1687-50,ATGP1687-100,ATGP1687-250,ATGP1687-500,ATGP1687-1

more info or order :

NKMAX product webpage