Recombinant human C4BPB protein | NKMAX ATGP1664 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human C4BPB protein

catalog :

ATGP1664

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human C4BPB protein

Domain :

18-252aa

Catalog number (SKU) :

ATGP1664

NCBI :

NP_000707

Description :

C4BPB is a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain of this protein assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. Recombinant human C4BPB protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

Complement component 4 binding protein beta, C4BP, C4b-binding protein beta chain

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.15M NaCl

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Carlsson,S.et al. (2010) J. Biol. Chem. 285 (42), 32038-32046;; Buil,A., et al. (2010) Blood 115 (23), 4644-4650

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

29kDa (260aa) confirmed by MALDI-TOF

Amino Acid Sequence :

SDAEH CPELPPVDNS IFVAKEVEGQ ILGTYVCIKG YHLVGKKTLF CNASKEWDNT TTECRLGHCP DPVLVNGEFS SSGPVNVSDK ITFMCNDHYI LKGSNRSQCL EDHTWAPPFP ICKSRDCDPP GNPVHGYFEG NNFTLGSTIS YYCEDRYYLV GVQEQQCVDG EWSSALPVCK LIQEAPKPEC EKALLAFQES KNLCEAMENF MQQLKESGMT MEELKYSLEL KKAELKAKLL

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P20851

Internal Search Terms :

C4BPB,ATGP1664-10ug,ATGP1664-20ug,ATGP1664-50ug,ATGP1664-100ug,ATGP1664-250ug,ATGP1664-500ug,ATGP1664-1mg,ATGP1664-10,ATGP1664-20,ATGP1664-50,ATGP1664-100,ATGP1664-250,ATGP1664-500,ATGP1664-1

References with this Product :

Sugimoto M, et al. Increased expression of Protein S in eyes with diabetic retinopathy and diabetic macular edema. (Sci Rep. 2021){https://pubmed.ncbi.nlm.nih.gov/34001977/};;Urawa M, et al. Protein S is protective in pulmonary fibrosis. (J Thromb Haemost. 2016){https://pubmed.ncbi.nlm.nih.gov/27172994/};;Yasuma T, et al. Amelioration of Diabetes by Protein S. (Diabetes. 2016){https://pubmed.ncbi.nlm.nih.gov/27207541/}

more info or order :

NKMAX product webpage